Adipose tissue is an active endocrine organ that can secrete a wide number of factors to
regulate adipogenesis via paracrine signals. In addition to soluble proteins in adipose …

Abstract Retinol binding protein-4 (RBP4) is a new adipokine synthesized by the liver and
adipose tissue, and its secretion depends on retinol concentrations and reflects visceral fat …

Many adipose tissue‐related diseases, such as obesity and type 2 diabetes, are worldwide
epidemics. For studying these diseases, relevant human cell models are needed. In this …

Aim: To define the genomic distribution and function of DNA methylation changes during
human adipogenesis. Methods: We isolated adipocyte-derived stem cells from 13 …

摘要诱导细胞凋亡DFF45 样效应子a (cell death inducing DNA fragmentation factor 45 like
effector a, CIDEa) 是一类和脂类代谢紧密相关的蛋白, 参与调控脂解, 脂滴的生长融合和极低 …

Inflammation has been proven significant factor in development of type 2 diabetes. So far,
most of the adipose tissue related research has been performed in animals, mainly rodent …

Traditional animal testing for toxicity is expensive, time consuming, ethically questioned,
sometimes inaccurate because of the necessity to extrapolate from animal to human, and in …

Costs of drug development are estimated at over $2 billion per drug. There is a need for
improved in vitro models that more accurately predict in vivo pharmacokinetics and improve …

Besides being an energy store, adipose tissue is an endocrine organ closely associated
with the vascular system. Human relevant in vitro models are needed to study adipose tissue …

The development of cell methods for the toxicity evaluation of drugs and chemicals started in
Scandinavia at the end of the 1970s. The pioneer in vitro toxicologist was Björn Ekwall …