Cytokine release syndrome (CRS) and nicotine in COVID-19 patients: trying to calm the storm

J Gonzalez-Rubio, C Navarro-Lopez… - Frontiers in …, 2020 - frontiersin.org
SARS-CoV-2 is a new coronavirus that has caused a worldwide pandemic. It causes severe
acute respiratory syndrome (COVID-19), which is fatal in many cases, and is characterized …

The Lord of the NanoRings: Cyclodextrins and the battle against SARS-CoV-2

PF Garrido, M Calvelo, A Blanco-Gonzalez… - International journal of …, 2020 - Elsevier
A handful of singular structures and laws can be observed in nature. They are not always
evident but, once discovered, it seems obvious how to take advantage of them. In chemistry …

Sociodemographic determinants and clinical risk factors associated with COVID-19 severity: a cross-sectional analysis of over 200,000 patients in Tehran, Iran

MR Sohrabi, R Amin, A Maher… - BMC infectious …, 2021 - Springer
Background Defining socio-demographic factors, clinical presentations and underlying
diseases associated with COVID-19 severity could be helpful in its management. This study …

Beyond smoking cessation: investigating medicinal nicotine to prevent and treat COVID-19

HA Tindle, PA Newhouse… - Nicotine and Tobacco …, 2020 - academic.oup.com
In the absence of treatment or a vaccine, the SARS-CoV-2 pandemic challenges the medical
community to identify novel containment strategies. Changeux et al. 1 have proposed the …

Regulation of the acetylcholine/α7nAChR anti-inflammatory pathway in COVID-19 patients

A Courties, J Boussier, J Hadjadj, N Yatim… - Scientific Reports, 2021 - nature.com
The cholinergic system has been proposed as a potential regulator of COVID-19-induced
hypercytokinemia. We investigated whole-blood expression of cholinergic system members …

Targeting the cholinergic anti-inflammatory pathway with vagus nerve stimulation in patients with Covid-19?

B Bonaz, V Sinniger, S Pellissier - Bioelectronic medicine, 2020 - Springer
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), at the origin of the
worldwide COVID-19 pandemic, is characterized by a dramatic cytokine storm in some …

Nicotine and the nicotinic cholinergic system in COVID‐19

Y Tizabi, B Getachew, RL Copeland… - The FEBS …, 2020 - Wiley Online Library
There is an urgent need to address the devastating pandemic, COVID‐19, caused by SARS‐
CoV‐2. The efforts to understand the details of this disease in hope of providing effective …

Nicotine: Regulatory roles and mechanisms in atherosclerosis progression

X Fu, T Zong, P Yang, L Li, S Wang, Z Wang… - Food and Chemical …, 2021 - Elsevier
Smoking is an independent risk factor for atherosclerosis. The smoke produced by tobacco
burning contains more than 7000 chemicals, among which nicotine is closely related to the …

Tobacco, but not nicotine and flavor-less electronic cigarettes, induces ACE2 and immune dysregulation

AC Lee, J Chakladar, WT Li, C Chen… - International journal of …, 2020 - mdpi.com
The COVID-19 pandemic caused by the SARS-CoV-2 virus, overlaps with the ongoing
epidemics of cigarette smoking and electronic cigarette (e-cig) vaping. However, there is …

The broad spectrum host-directed agent ivermectin as an antiviral for SARS-CoV-2?

DA Jans, KM Wagstaff - Biochemical and Biophysical Research …, 2021 - Elsevier
FDA approved for parasitic indications, the small molecule ivermectin has been the focus of
growing attention in the last 8 years due to its potential as an antiviral. We first identified …