Microglia phenotypes in aging and neurodegenerative diseases

MY Wendimu, SB Hooks - Cells, 2022 - mdpi.com
Neuroinflammation is a hallmark of many neurodegenerative diseases (NDs) and plays a
fundamental role in mediating the onset and progression of disease. Microglia, which …

Global brain inflammation in stroke

K Shi, DC Tian, ZG Li, AF Ducruet, MT Lawton… - The Lancet …, 2019 - thelancet.com
Stroke, including acute ischaemic stroke and intracerebral haemorrhage, results in neuronal
cell death and the release of factors such as damage-associated molecular patterns …

Action plan for stroke in Europe 2018–2030

B Norrving, J Barrick, A Davalos… - European stroke …, 2018 - journals.sagepub.com
Two previous pan-European consensus meetings, the 1995 and 2006 Helsingborg
meetings, were convened to review the scientific evidence and the state of current services …

Modulators of microglial activation and polarization after intracerebral haemorrhage

X Lan, X Han, Q Li, QW Yang, J Wang - Nature Reviews Neurology, 2017 - nature.com
Intracerebral haemorrhage (ICH) is the most lethal subtype of stroke but currently lacks
effective treatment. Microglia are among the first non-neuronal cells on the scene during the …

[HTML][HTML] Neuroinflammation after intracerebral hemorrhage and potential therapeutic targets

C Tschoe, CD Bushnell, PW Duncan… - Journal of …, 2020 - ncbi.nlm.nih.gov
Spontaneous intracerebral hemorrhage (ICH) is a catastrophic illness causing significant
morbidity and mortality. Despite advances in surgical technique addressing primary brain …

Functions and mechanisms of microglia/macrophages in neuroinflammation and neurogenesis after stroke

XY Xiong, L Liu, QW Yang - Progress in neurobiology, 2016 - Elsevier
Microglia/macrophages are the major immune cells involved in the defence against brain
damage. Their morphology and functional changes are correlated with the release of danger …

TREM2 activation attenuates neuroinflammation and neuronal apoptosis via PI3K/Akt pathway after intracerebral hemorrhage in mice

S Chen, J Peng, P Sherchan, Y Ma, S Xiang… - Journal of …, 2020 - Springer
Background Neuroinflammation is an important host defense response to secondary brain
injury after intracerebral hemorrhage (ICH). Triggering receptor expressed on myeloid cells …

Neuroinflammation in acute ischemic and hemorrhagic stroke

DL Alsbrook, M Di Napoli, K Bhatia, J Biller… - Current neurology and …, 2023 - Springer
Abstract Purpose of Review This review aims to provide an overview of neuroinflammation
in ischemic and hemorrhagic stroke, including recent findings on the mechanisms and …

Irisin ameliorates neuroinflammation and neuronal apoptosis through integrin αVβ5/AMPK signaling pathway after intracerebral hemorrhage in mice

Y Wang, M Tian, J Tan, X Pei, C Lu, Y Xin… - Journal of …, 2022 - Springer
Background Neuroinflammation is a crucial factor in the development of secondary brain
injury after intracerebral hemorrhage (ICH). Irisin is a newly identified myokine that confers …

Role and mechanisms of cytokines in the secondary brain injury after intracerebral hemorrhage

H Zhu, Z Wang, J Yu, X Yang, F He, Z Liu, F Che… - Progress in …, 2019 - Elsevier
Intracerebral hemorrhage (ICH) is a common and severe cerebrovascular disease that has
high mortality. Few survivors achieve self-care. Currently, patients receive only symptomatic …