Immunological lessons from respiratory syncytial virus vaccine development

TJ Ruckwardt, KM Morabito, BS Graham - Immunity, 2019 - cell.com
Respiratory syncytial virus (RSV) has eluded active vaccination efforts for more than five
decades and continues to cause substantial morbidity and mortality in infants, the …

Vaccination strategies to enhance immunity in neonates

TR Kollmann, A Marchant, SS Way - Science, 2020 - science.org
Neonates are particularly susceptible to infection. This vulnerability occurs despite their
responsiveness to most vaccines. However, current vaccines do not target the pathogens …

[PDF][PDF] Empfehlungen der Ständigen Impfkommission (STIKO) beim Robert Koch-Institut 2024

S Impfkommission - 2024 - edoc.rki.de
Die Impfempfehlungen der Ständigen Impfkommission (STIKO) wurden auf der 106. Sitzung
der STIKO verabschiedet. Die folgenden Ausführungen ersetzen die im Epidemiologischen …

Safety and immunogenicity of an investigational respiratory syncytial virus vaccine (RSVPreF3) in mothers and their infants: a phase 2 randomized trial

Z Bebia, O Reyes, R Jeanfreau… - The Journal of …, 2023 - academic.oup.com
Background In a phase 1/2 study, a maternal respiratory syncytial virus vaccine candidate
(RSVPreF3) demonstrated an acceptable safety profile and efficiently increased RSV …

The adaptive immune system in early life: The shift makes it count

DKJ Pieren, MC Boer, J de Wit - Frontiers in immunology, 2022 - frontiersin.org
Respiratory infectious diseases encountered early in life may result in life-threatening
disease in neonates, which is primarily explained by the relatively naive neonatal immune …

Maternal antibody response and transplacental transfer following severe acute respiratory syndrome coronavirus 2 infection or vaccination in pregnancy

S Otero, ES Miller, A Sunderraj… - Clinical Infectious …, 2023 - academic.oup.com
Background Pregnant persons are at increased risk of severe coronavirus disease 2019
(COVID-19) and adverse obstetric outcomes. Understanding maternal antibody response …

The impact of COVID-19 in pregnancy: Part II. Vaccination to pregnant women

PH Wang, WL Lee, ST Yang, KH Tsui… - Journal of the …, 2021 - journals.lww.com
Effective strategies are urgently needed to decrease the risk of untoward outcomes of
pregnant women with severe acute respiratory syndrome coronavirus 2 (coronavirus …

[HTML][HTML] Safety and immunogenicity of an investigational maternal trivalent group B streptococcus vaccine in pregnant women and their infants: Results from a …

GK Swamy, TD Metz, KM Edwards, DE Soper, RH Beigi… - Vaccine, 2020 - Elsevier
Background This study evaluated the safety and immunogenicity of an investigational
trivalent group B streptococcus (GBS) vaccine in US pregnant women, transplacental …

Safety and immunogenicity of a respiratory syncytial virus prefusion F vaccine when coadministered with a tetanus, diphtheria, and acellular pertussis vaccine

JT Peterson, AM Zareba, D Fitz-Patrick… - The Journal of …, 2022 - academic.oup.com
Background Prevention of respiratory syncytial virus (RSV) disease in infants is an unmet
vaccine need, and maternal immunization is a potential strategy to address this need. This …

Three dose levels of a maternal respiratory syncytial virus vaccine candidate are well tolerated and immunogenic in a randomized trial in nonpregnant women

TF Schwarz, C Johnson, C Grigat… - The Journal of …, 2022 - academic.oup.com
Background Respiratory syncytial virus (RSV) causes respiratory tract infections, which may
require hospitalization especially in early infancy. Transplacental transfer of RSV antibodies …