Rational use of tocilizumab in the treatment of novel coronavirus pneumonia

S Zhang, L Li, A Shen, Y Chen, Z Qi - Clinical drug investigation, 2020 - Springer
Since December 2019, a novel coronavirus pneumonia (COVID-19) has broken out in
Wuhan, China and spread rapidly. Recent studies have found that⁓ 15.7% of patients …

Baricitinib, a drug with potential effect to prevent SARS-COV-2 from entering target cells and control cytokine storm induced by COVID-19

X Zhang, Y Zhang, W Qiao, J Zhang, Z Qi - International …, 2020 - Elsevier
In December 2019, a novel coronavirus pneumonia (COVID-19) caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) suddenly broke out in China and rapidly …

Direct, indirect, post-infection damages induced by coronavirus in the human body: an overview

SP Priya, PM Sunil, S Varma, C Brigi, MFAR Isnadi… - Virusdisease, 2022 - Springer
Background Severe acute respiratory syndrome Coronavirus-2 invades the cells via ACE2
receptor and damages multiple organs of the human body. Understanding the pathological …

Study on the mechanism of treating COVID-19 with Shenqi Wan based on network pharmacology

X Ye, Y Deng, X Zhang, M Liu, Y Liu, Y Xie… - Drug Development …, 2021 - Taylor & Francis
Purpose Through the method of network pharmacology, the active components and targets
of Shenqi Wan (SQW) were excavated, the relationship with novel Coronavirus pneumonia …

Dietary Flavone Baicalein Combinate with Genipin Attenuates Inflammation Stimulated by Lipopolysaccharide in RAW264.7 Cells or Pseudomonas aeruginosa in …

M Zhang, L Ye, C Cheng, F Shen, L Niu, Y Hou, G Bai - Nutrients, 2021 - mdpi.com
Mounting evidence has shown that single-targeted therapy might be inadequate to achieve
satisfactory effects. Thus, drug combinations are gaining attention as they can regulate …

Using a System Pharmacology Method to Search for the Potential Targets and Pathways of Yinqiaosan against COVID‐19

L Cao, X Jia, H He, Z Wang, Y Zhao… - Journal of …, 2022 - Wiley Online Library
The first reported case of coronavirus disease 2019 (COVID‐19) occurred in Wuhan, Hubei,
China. Thereafter, it spread through China and worldwide in only a few months, reaching a …

A potent leukocyte transmigration blocker: GT-73 showed a protective effect against LPS-induced ARDS in mice

E Blum, R Margalit, L Levy, T Getter, R Lahav, S Zilber… - Molecules, 2021 - mdpi.com
We recently developed a molecule (GT-73) that blocked leukocyte transendothelial
migration from blood to the peripheral tissues, supposedly by affecting the platelet …

[HTML][HTML] 苦参碱氯化钠注射液对人冠状病毒肺炎寒湿疫毒袭肺证小鼠病证结合模型的治疗作用

孙静, 赵荣华, 郭姗姗, 时宇静, 包蕾, 耿子涵, 高英杰… - 药学学报, 2020 - html.rhhz.net
" 疫毒袭肺证" 是北京市中医管理局对新型冠状病毒感染肺炎的中医病证分类,
本研究首次建立了与新型冠状病毒中医寒湿疫毒袭肺证相吻合的病证结合小鼠模型 …

[PDF][PDF] Molecular mechanism prediction analysis of compound Kushen injection in the treatment of COVID-19 based on network pharmacology and molecular docking

WY Zhang, Y Chen, MM Zhang… - Traditional Medicine …, 2020 - tmrjournals.com
Background: As one of the eight effective traditional Chinese medicines for the treatment of
atypical pneumonia, compound Kushen injection (CKI) played an important role in …

Sphingoid compounds for prophylaxis and/or therapy of coronaviridae infection

E Gulbins - US Patent 11,298,412, 2022 - Google Patents
Provided are processes for the prevention or treatment of infection by SARS-CoV-2. Some
aspects provide adminis tration of a sphingoid compound, optionally sphingosine, an active …