Network analysis of depression and anxiety symptom relationships in a psychiatric sample
BackgroundResearchers have studied psychological disorders extensively from a common
cause perspective, in which symptoms are treated as independent indicators of an …
cause perspective, in which symptoms are treated as independent indicators of an …
[HTML][HTML] Cell type-specific transcriptomics reveals that mutant huntingtin leads to mitochondrial RNA release and neuronal innate immune activation
The mechanisms by which mutant huntingtin (mHTT) leads to neuronal cell death in
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
Huntington's disease (HD) are not fully understood. To gain new molecular insights, we …
The Genotype-Tissue Expression (GTEx) pilot analysis: multitissue gene regulation in humans
Understanding the functional consequences of genetic variation, and how it affects complex
human disease and quantitative traits, remains a critical challenge for biomedicine. We …
human disease and quantitative traits, remains a critical challenge for biomedicine. We …
Shared molecular neuropathology across major psychiatric disorders parallels polygenic overlap
MJ Gandal, JR Haney, NN Parikshak, V Leppa… - Science, 2018 - science.org
The predisposition to neuropsychiatric disease involves a complex, polygenic, and
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
pleiotropic genetic architecture. However, little is known about how genetic variants impart …
Genome-wide changes in lncRNA, splicing, and regional gene expression patterns in autism
Autism spectrum disorder (ASD) involves substantial genetic contributions. These
contributions are profoundly heterogeneous but may converge on common pathways that …
contributions are profoundly heterogeneous but may converge on common pathways that …
[HTML][HTML] The Mount Sinai cohort of large-scale genomic, transcriptomic and proteomic data in Alzheimer's disease
Alzheimer's disease (AD) affects half the US population over the age of 85 and is universally
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
fatal following an average course of 10 years of progressive cognitive disability. Genetic and …
Transcriptomic organization of the human brain in post-traumatic stress disorder
Despite extensive study of the neurobiological correlates of post-traumatic stress disorder
(PTSD), little is known about its molecular determinants. Here, differential gene expression …
(PTSD), little is known about its molecular determinants. Here, differential gene expression …
[HTML][HTML] Single-cell RNA-seq reveals dynamic change in tumor microenvironment during pancreatic ductal adenocarcinoma malignant progression
K Chen, Q Wang, M Li, H Guo, W Liu, F Wang, X Tian… - …, 2021 - thelancet.com
Background Pancreatic ductal adenocarcinoma (PDAC) is most aggressive among all
gastrointestinal tumors. The complex intra-tumor heterogeneity and special tumor …
gastrointestinal tumors. The complex intra-tumor heterogeneity and special tumor …
[HTML][HTML] Personalized immunomonitoring uncovers molecular networks that stratify lupus patients
Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by loss of
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
tolerance to nucleic acids and highly diverse clinical manifestations. To assess its molecular …
Chromosome conformation elucidates regulatory relationships in developing human brain
Three-dimensional physical interactions within chromosomes dynamically regulate gene
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …
expression in a tissue-specific manner,,. However, the 3D organization of chromosomes …