The Perseus computational platform for comprehensive analysis of (prote) omics data
A main bottleneck in proteomics is the downstream biological analysis of highly multivariate
quantitative protein abundance data generated using mass-spectrometry-based analysis …
quantitative protein abundance data generated using mass-spectrometry-based analysis …
The human transcriptome across tissues and individuals
Transcriptional regulation and posttranscriptional processing underlie many cellular and
organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue …
organismal phenotypes. We used RNA sequence data generated by Genotype-Tissue …
Progranulin deficiency promotes circuit-specific synaptic pruning by microglia via complement activation
H Lui, J Zhang, SR Makinson, MK Cahill, KW Kelley… - Cell, 2016 - cell.com
Microglia maintain homeostasis in the brain, but whether aberrant microglial activation can
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
cause neurodegeneration remains controversial. Here, we use transcriptome profiling to …
What are'good'depression symptoms? Comparing the centrality of DSM and non-DSM symptoms of depression in a network analysis
Abstract Background The symptoms for Major Depression (MD) defined in the DSM-5 differ
markedly from symptoms assessed in common rating scales, and the empirical question …
markedly from symptoms assessed in common rating scales, and the empirical question …
Spatially resolved transcriptomics reveals genes associated with the vulnerability of middle temporal gyrus in Alzheimer's disease
Human middle temporal gyrus (MTG) is a vulnerable brain region in early Alzheimer's
disease (AD), but little is known about the molecular mechanisms underlying this regional …
disease (AD), but little is known about the molecular mechanisms underlying this regional …
Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease
Background Disease-associated-microglia (DAM) represent transcriptionally-distinct and
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
neurodegeneration-specific microglial profiles with unclear significance in Alzheimer's …
Environmental DNA reveals seasonal shifts and potential interactions in a marine community
Environmental DNA (eDNA) analysis allows the simultaneous examination of organisms
across multiple trophic levels and domains of life, providing critical information about the …
across multiple trophic levels and domains of life, providing critical information about the …
Impaired neurogenesis alters brain biomechanics in a neuroprogenitor-based genetic subtype of congenital hydrocephalus
Hydrocephalus, characterized by cerebral ventricular dilatation, is routinely attributed to
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …
primary defects in cerebrospinal fluid (CSF) homeostasis. This fosters CSF shunting as the …
Brain network dynamics during working memory are modulated by dopamine and diminished in schizophrenia
Dynamical brain state transitions are critical for flexible working memory but the network
mechanisms are incompletely understood. Here, we show that working memory …
mechanisms are incompletely understood. Here, we show that working memory …
A molecular network of the aging human brain provides insights into the pathology and cognitive decline of Alzheimer's disease
S Mostafavi, C Gaiteri, SE Sullivan, CC White… - Nature …, 2018 - nature.com
There is a need for new therapeutic targets with which to prevent Alzheimer's disease (AD),
a major contributor to aging-related cognitive decline. Here we report the construction and …
a major contributor to aging-related cognitive decline. Here we report the construction and …