Gene expression elucidates functional impact of polygenic risk for schizophrenia
Over 100 genetic loci harbor schizophrenia-associated variants, yet how these variants
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
confer liability is uncertain. The CommonMind Consortium sequenced RNA from …
[HTML][HTML] Design and computational analysis of single-cell RNA-sequencing experiments
R Bacher, C Kendziorski - Genome biology, 2016 - Springer
Single-cell RNA-sequencing (scRNA-seq) has emerged as a revolutionary tool that allows
us to address scientific questions that eluded examination just a few years ago. With the …
us to address scientific questions that eluded examination just a few years ago. With the …
State of the aRt personality research: A tutorial on network analysis of personality data in R
Network analysis represents a novel theoretical approach to personality. Network
approaches motivate alternative ways of analyzing data, and suggest new ways of modeling …
approaches motivate alternative ways of analyzing data, and suggest new ways of modeling …
[HTML][HTML] Oxytocin pathway gene networks in the human brain
Oxytocin is a neuropeptide involved in animal and human reproductive and social behavior.
Three oxytocin signaling genes have been frequently implicated in human social behavior …
Three oxytocin signaling genes have been frequently implicated in human social behavior …
Transcriptional landscape of the prenatal human brain
The anatomical and functional architecture of the human brain is mainly determined by
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …
prenatal transcriptional processes. We describe an anatomically comprehensive atlas of the …
Changes in structural and functional connectivity among resting-state networks across the human lifespan
At rest, the brain's sensorimotor and higher cognitive systems engage in organized patterns
of correlated activity forming resting-state networks. An important empirical question is how …
of correlated activity forming resting-state networks. An important empirical question is how …
[HTML][HTML] How well do network models predict observations? On the importance of predictability in network models
JMB Haslbeck, LJ Waldorp - Behavior research methods, 2018 - Springer
Network models are an increasingly popular way to abstract complex psychological
phenomena. While studying the structure of network models has led to many important …
phenomena. While studying the structure of network models has led to many important …
[HTML][HTML] Transformative network modeling of multi-omics data reveals detailed circuits, key regulators, and potential therapeutics for Alzheimer's disease
To identify the molecular mechanisms and novel therapeutic targets of late-onset
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Alzheimer's Disease (LOAD), we performed an integrative network analysis of multi-omics …
Correlated gene expression supports synchronous activity in brain networks
During rest, brain activity is synchronized between different regions widely distributed
throughout the brain, forming functional networks. However, the molecular mechanisms …
throughout the brain, forming functional networks. However, the molecular mechanisms …
[HTML][HTML] Modeling gene× environment interactions in PTSD using human neurons reveals diagnosis-specific glucocorticoid-induced gene expression
Post-traumatic stress disorder (PTSD) can develop following severe trauma, but the extent to
which genetic and environmental risk factors contribute to individual clinical outcomes is …
which genetic and environmental risk factors contribute to individual clinical outcomes is …