On August 30, 2017, the US Food and Drug Administration (FDA) approved Novartis'
tisagenlecleucel (CTL-019, Kymriah), which is a synthetic bioimmune product of anti-CD19 …

The biological regulation of transcription factors (TFs) and repressor proteins is an important
mechanism for maintaining cell homeostasis. In B cell acute lymphoblastic leukemia (B-ALL) …

Acute Lymphoblastic Leukemia (ALL) is an aggressive hematologic disorder and constitutes
approximately 25% of cancer diagnoses among children and teenagers. Pediatric patients …

Abstract t (4; 11) MLL-AF4 acute leukemia is one of the most aggressive malignancies in the
infant and pediatric population, yet we have little information on the molecular mechanisms …

Simple Summary B cells are an essential component of the immune system and develop in
the bone marrow microenvironment. B-cell development is tightly regulated by the stromal …

Background Acute lymphoid leukaemia (ALL) is the commonest childhood cancer whose
incidence is rising in many nations. In the USA, between 1975 and 2016, ALL rates (ALLRs) …

Background: Twelve separate streams of empirical data make a strong case for cannabis-
induced accelerated aging including hormonal, mitochondriopathic, cardiovascular …

E2A, a basic helix-loop-helix transcription factor, plays a crucial role in determining tissue-
specific cell fate, including differentiation of B-cell lineages. In 5% of childhood acute …

Recent European data facilitate an epidemiological investigation of the controversial
cannabis–cancer relationship. Of particular concern were prior findings associating high …

Introduction Over the years, the Hispanic population living in the United States has
consistently shown high incidence rates of childhood acute leukemias (AL). Similarly, high …