Recognition of invading pathogens by the innate immune system is essential to initiate
antimicrobial responses and trigger adaptive immunity. This is largely mediated by an array …

Toll-like receptor 7 (TLR7) is a class of pattern recognition receptors (PRRs) recognizing the
pathogen-associated elements and damage and as such is a major player in the innate …

Earth-abundant metal (EAM) catalysis can have profound impact in the pharmaceutical
industry in terms of sustainability and cost improvements from replacing precious metals like …

As sp2–sp3 disconnections gain acceptance in the medicinal chemist's toolbox, an
increasing number of potential drug candidates containing this motif are moving into the …

Cobalt (II) halides in combination with phenoxyimine (FI) ligands generated efficient
precatalysts in situ for the C (sp2)–C (sp3) Suzuki–Miyaura cross-coupling between alkyl …

The sensing of self RNA by the endosomal Toll-like receptors (TLRs) 7 and 8 initiates
pathogenic mechanisms underlying the autoimmune disease lupus. A blockade of the …

Toll-like receptors (TLRs) are members of a large family of evolutionarily conserved pattern
recognition receptors (PRRs), which serve as key components of the innate immune system …

Nucleic acid nanoparticles (NANPs) represent a highly versatile molecular platform for the
targeted delivery of various therapeutics. However, despite their promise, further clinical …

To fully evaluate and define the new drug molecule for its pharmacological characteristics
and toxicity profile, pre-clinical and clinical studies are conducted as part of the drug …

Undesirable activation of endosomal toll-like receptors TLR7 and TLR9 present in specific
immune cells in response to host-derived ligands is implicated in several autoimmune …