Inflammatory bowel diseases are characterised by inflammation that compromises the
integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has …

A complex mucosal barrier protects as the first line of defense the surface of the healthy
intestinal tract from adhesion and invasion by luminal microorganisms. In this review, we …

The importance of gut microbiota in human health and pathophysiology is undisputable.
Despite the abundance of metagenomics data, the functional dynamics of gut microbiota in …

Background Macrophages are key players in inflammatory bowel diseases (IBD). This study
aimed to determine site-specific effects of defined macrophage subtypes on the integrity of …

BACKGROUND: Atopic dermatitis (AD) is characterized by dry skin and a hyperactive
immune response to allergens, 2 cardinal features that are caused in part by epidermal …

The molecular checkpoints that drive inflammatory bowel diseases are incompletely
understood. Here we found more T cells expressing the transcription factor PU. 1 and …

Aims Inflammatory bowel disease (IBD) patients are accompanied by impaired intestinal
barrier integrity and gut microbiota dysbiosis. Strategies targeting the gut microbiota are …

BACKGROUND: Chronic rhinosinusitis (CRS) is a common disease with still unclear
pathophysiologic mechanisms. Epithelial tight junctions (TJs) have been shown to be …

The current paradigm of inflammatory bowel diseases (IBD), both Crohn's disease (CD) and
ulcerative colitis (UC), involves the interaction between environmental factors in the …

An essential role of the intestinal epithelium is to separate luminal contents from the
interstitium, a function primarily determined by the integrity of the epithelium and the tight …