Background—Immunoreactive signal for the desmosomal protein plakoglobin (γ-catenin) is
reduced at cardiac intercalated disks in patients with arrhythmogenic right ventricular …

Background Dextran sodium sulfate (DSS) is used to induce murine colitis. Although the
exact mechanism by which DSS administration causes disease is unknown, evidence …

The breakdown of the intestinal barrier is a common manifestation of many diseases. Recent
evidence suggests that vitamin D and its receptor VDR may regulate intestinal barrier …

BACKGROUND & AIMS: Hypoxia inducible factor (HIF) prolyl hydroxylase inhibitors are
protective in mouse models of inflammatory bowel disease (IBD). Here, we investigated the …

Objective This study aimed to evaluate the effects of ingested periodontal pathogens on
experimental colitis in mice and to elucidate its underlying mechanisms. Background …

The pathogenesis of inflammatory bowel diseases (IBDs) seems to involve a primary defect
in one or more of the elements responsible for the maintenance of intestinal homeostasis …

The micronutrients zinc, quercetin, butyrate, indole and berberine were evaluated for their
ability to induce remodeling of epithelial tight junctions (TJs) and enhance barrier integrity in …

Gut homeostasis plays an important role in maintaining animal and human health. The
disruption of gut homeostasis has been shown to be associated with multiple diseases. The …

Ulcerative colitis (UC) is a chronic inflammatory bowel disease impacting patients' quality of
life and imposing heavy societal and economic burdens. Apoptosis of intestinal epithelial …

Probiotic bacteria are recognized for their health-promoting properties, including
maintenance of gut epithelial integrity and host immune system homeostasis. Taking into …