[HTML][HTML] Key role of short-chain fatty acids in epithelial barrier failure during ruminal acidosis

S Meissner, F Hagen, C Deiner, D Günzel, G Greco… - Journal of dairy …, 2017 - Elsevier
Subacute ruminal acidosis is induced by high concentrations of short-chain fatty acids
(SCFA, mainly acetate, propionate, and butyrate) that release protons to decrease the pH of …

Intestinal barrier integrity and inflammatory bowel disease: Stem cell‐based approaches to regenerate the barrier

FEO Holmberg, J Pedersen… - Journal of tissue …, 2018 - Wiley Online Library
Disruption of normal barrier function is a fundamental factor in the pathogenesis of
inflammatory bowel disease, which includes increased epithelial cell death, modified mucus …

[HTML][HTML] Increased intestinal permeability in inflammatory bowel diseases assessed by iohexol test

VA Gerova, SG Stoynov, DS Katsarov… - World journal of …, 2011 - ncbi.nlm.nih.gov
AIM: To study intestinal permeability (IP) and its relationship to the disease activity in
patients with inflammatory bowel diseases (IBD)-Crohn's disease (CD) and ulcerative colitis …

Gallic acid mitigates LPS‐induced inflammatory response via suppressing NF‐κB signalling pathway in IPEC‐J2 cells

L Cai, Z Wei, X Zhao, Y Li, X Li… - Journal of Animal …, 2022 - Wiley Online Library
Gallic acid is a phenolic compound that exhibits antibacterial, antioxidative and anti‐
inflammatory functions. In a previous study, we found that dietary supplementation with gallic …

Role of farnesoid X receptor in inflammation and resolution

FB Shaik, DVR Prasad, VR Narala - Inflammation Research, 2015 - Springer
Objective The aim of this paper is to review the developments of farnesoid X receptor (FXR)
biology, its ligands, and various functions, in particular we discuss the anti-inflammatory and …

Adherent-invasive Escherichia coli Induce Claudin-2 Expression and Barrier Defect in CEABAC10 Mice and Crohn's Disease Patients

J Denizot, A Sivignon, F Barreau… - Inflammatory bowel …, 2012 - academic.oup.com
Background Abnormal expression of CEACAM6 observed on the ileal epithelium in Crohn's
disease (CD) patients allows adherent-invasive Escherichia coli (AIEC) to colonize gut …

Cocaine induces inflammatory gut milieu by compromising the mucosal barrier integrity and altering the gut microbiota colonization

ET Chivero, R Ahmad, A Thangaraj, P Periyasamy… - Scientific reports, 2019 - nature.com
Cocaine use disorder (CUD), a major health crisis, has traditionally been considered a
complication of the CNS; however, it is also closely associated with malnourishment and …

[HTML][HTML] Exploring the effects of phenolic compounds to reduce intestinal damage and improve the intestinal barrier integrity: A systematic review of in vivo animal …

BA Sandoval-Ramírez, Ú Catalán, A Pedret, RM Valls… - Clinical Nutrition, 2021 - Elsevier
Background & aims The integrity of the intestinal barrier in the diseased is key to prevent
further complications and disease such as sepsis and death, whereas, the role of food …

Eicosanoid receptors: Targets for the treatment of disrupted intestinal epithelial homeostasis

JJ Moreno - European Journal of Pharmacology, 2017 - Elsevier
The importance of cyclooxygenase and lipoxygenase pathways and the consequent
eicosanoid synthesis in the physiology and pathophysiology of the intestinal epithelium is …

Farnesoid X receptor activation attenuates intestinal ischemia reperfusion injury in rats

LJ Ceulemans, L Verbeke, JP Decuypere, R Farre… - PloS one, 2017 - journals.plos.org
Introduction The farnesoid X receptor (FXR) is abundantly expressed in the ileum, where it
exerts an enteroprotective role as a key regulator of intestinal innate immunity and …