Longitudinal epigenetic and gene expression profiles analyzed by three-component analysis reveal down-regulation of genes involved in protein translation in human …
Data on biological mechanisms of aging are mostly obtained from cross-sectional study
designs. An inherent disadvantage of this design is that inter-individual differences can …
designs. An inherent disadvantage of this design is that inter-individual differences can …
Epigenetic age acceleration and clinical outcomes in gliomas
Epigenetic age acceleration—the difference between an individual's DNA methylation age
and chronological age—is associated with many diseases including cancer. This study aims …
and chronological age—is associated with many diseases including cancer. This study aims …
[PDF][PDF] Methylome analysis of human bone marrow MSCs reveals extensive age-and culture-induced changes at distal regulatory elements
KK Pasumarthy, ND Jayavelu, L Kilpinen, C Andrus… - Stem Cell Reports, 2017 - cell.com
Human bone marrow stromal cells, or mesenchymal stem cells (BM-MSCs), need expansion
prior to use as cell-based therapies in immunological and tissue repair applications. Aging …
prior to use as cell-based therapies in immunological and tissue repair applications. Aging …
[HTML][HTML] Brain Region-and Age-Dependent 5-Hydroxymethylcytosine Activity in the Non-Human Primate
Y Xu, L Zhong, H Wei, Y Li, J Xie, L Xie… - Frontiers in Aging …, 2022 - frontiersin.org
Because of difficulty in collecting fresh brains of humans at different ages, it remains
unknown how the epigenetic regulation occurs in the primate brains during aging. In the …
unknown how the epigenetic regulation occurs in the primate brains during aging. In the …
Testing of geroprotectors in experiments on cell cultures: pros and cons
AN Khokhlov, GV Morgunova - 2017 - books.rsc.org
According to the classic definition of aging we share, it is a combination of changes in an
organism leading to an increase in the probability of its death (rate of mortality). 1–4 It should …
organism leading to an increase in the probability of its death (rate of mortality). 1–4 It should …
[PDF][PDF] Accurate age prediction from blood using a small set of DNA methylation sites and a cohort-based machine learning algorithm
Chronological age prediction from DNA methylation sheds light on human aging, health,
and lifespan. Current clocks are mostly based on linear models and rely upon hundreds of …
and lifespan. Current clocks are mostly based on linear models and rely upon hundreds of …
Methyl-CpG-binding domain sequencing: MBD-seq
Detailed biological knowledge about the potential importance of the methylome is typically
lacking for common diseases. Therefore, methylome-wide association studies (MWAS) are …
lacking for common diseases. Therefore, methylome-wide association studies (MWAS) are …
Novel regional age-associated DNA methylation changes within human common disease-associated loci
Background Advancing age progressively impacts on risk and severity of chronic disease. It
also modifies the epigenome, with changes in DNA methylation, due to both random drift …
also modifies the epigenome, with changes in DNA methylation, due to both random drift …
Differential gene expression analysis in ageing muscle and drug discovery perspectives
Identifying therapeutic target genes represents the key step in functional genomics-based
therapies. Within this context, the disease heterogeneity, the exogenous factors and the …
therapies. Within this context, the disease heterogeneity, the exogenous factors and the …
Robustness during aging—molecular biological and physiological aspects
Understanding the process of aging is still an important challenge to enable healthy aging
and to prevent age-related diseases. Most studies in age research investigate the decline in …
and to prevent age-related diseases. Most studies in age research investigate the decline in …