The role of interleukin-8 in lung inflammation and injury: implications for the management of COVID-19 and hyperinflammatory acute respiratory distress syndrome

MC Cesta, M Zippoli, C Marsiglia, EM Gavioli… - Frontiers in …, 2022 - frontiersin.org
Severe Acute Respiratory Syndrome Coronavirus—2 (SARS CoV-2) has resulted in the
global spread of Coronavirus Disease 2019 (COVID-19) and an increase in complications …

Between inflammation and thrombosis: endothelial cells in COVID-19

A Birnhuber, E Fliesser, G Gorkiewicz… - European …, 2021 - Eur Respiratory Soc
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the current
coronavirus disease (COVID-19) pandemic [1]. Over recent months, a plethora of novel …

Distinct characteristics of COVID-19 infection in children

X Han, X Li, Y Xiao, R Yang, Y Wang, X Wei - Frontiers in Pediatrics, 2021 - frontiersin.org
SARS-CoV-2, a member of the family coronaviridae, has triggered a lethal pandemic termed
coronavirus disease 2019 (COVID-19). Pediatric patients, mainly from families with a cluster …

SARS-CoV-2 accessory proteins reveal distinct serological signatures in children

A Hachim, H Gu, O Kavian, M Mori, MYW Kwan… - Nature …, 2022 - nature.com
The antibody response magnitude and kinetics may impact clinical severity, serological
diagnosis and long-term protection of COVID-19, which may play a role in why children …

Tissue proteomic analysis identifies mechanisms and stages of immunopathology in fatal COVID-19

CD Russell, A Valanciute, NN Gachanja… - American journal of …, 2022 - atsjournals.org
Immunopathology occurs in the lung and spleen in fatal coronavirus disease (COVID-19),
involving monocytes/macrophages and plasma cells. Antiinflammatory therapy reduces …

A comparative study of the plasma chemokine profile in COVID-19 patients infected with different SARS-CoV-2 variants

ZR Korobova, NA Arsentieva, NE Liubimova… - International Journal of …, 2022 - mdpi.com
Background. Infection caused by SARS-CoV-2 mostly affects the upper and lower
respiratory tracts and causes symptoms ranging from the common cold to pneumonia with …

The relationship between peripheral immune response and disease severity in SARS‐CoV‐2‐infected subjects: A cross‐sectional study

LO Walter, CC Cardoso, ÍM Santos‐Pirath… - …, 2022 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19) is a respiratory infection caused by severe
acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and marked by an intense …

Replication kinetics, cell tropism, and associated immune responses in SARS-CoV-2-and H5N1 virus-infected human induced pluripotent stem cell-derived neural …

L Bauer, B Lendemeijer, L Leijten, CWE Embregts… - Msphere, 2021 - Am Soc Microbiol
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is associated with
a wide variety of neurological complications. Even though SARS-CoV-2 is rarely detected in …

Metformin suppresses monocyte immunometabolic activation by SARS-CoV-2 spike protein subunit 1

TJ Cory, RS Emmons, JR Yarbro, KL Davis… - Frontiers in …, 2021 - frontiersin.org
A hallmark of COVID-19 is a hyperinflammatory state associated with severity. Monocytes
undergo metabolic reprogramming and produce inflammatory cytokines when stimulated …

Simultaneous Targeting of IL-1–Signaling and IL-6–Trans-Signaling Preserves Human Pulmonary Endothelial Barrier Function During a Cytokine Storm—Brief Report

N Colás-Algora, P Muñoz-Pinillos… - … and Vascular Biology, 2023 - Am Heart Assoc
BACKGROUND: Systemic inflammatory diseases, such as sepsis and severe COVID-19,
provoke acute respiratory distress syndrome in which the pathological hyperpermeability of …