Vascular cognitive impairment (VCI) is predominately caused by vascular risk factors and
cerebrovascular disease. VCI includes a broad spectrum of cognitive disorders, from mild …

Transient or permanent loss of tissue perfusion due to ischaemic stroke can lead to damage
to the neurovasculature, and disrupt brain homeostasis, causing long-term motor and …

Importance Determining the long-term impact of COVID-19 on cognition is important to
inform immediate steps in COVID-19 research and health policy. Objective To investigate …

Alzheimer's disease (AD) is the most common cause of dementia and is characterized by
progressive neurodegeneration and cognitive decline. Understanding the pathophysiology …

Alzheimer disease (AD) is biologically defined by the presence of β-amyloid-containing
plaques and tau-containing neurofibrillary tangles. AD is a genetic and sporadic …

The incidence of age-related dementia is increasing as the world population ages and due
to lack of effective treatments for dementia. Vascular contributions to cognitive impairment …

Neuroinflammation and the tissue-resident innate immune cells, the microglia, respond and
contribute to neurodegenerative pathology. Although microglia have been the focus of work …

eNOS (endothelial nitric oxide synthase) is critically important enzyme responsible for
regulation of cardiovascular homeostasis. Under physiological conditions, constitutive eNOS …

The aging population worldwide is facing a significant increase in age-related non-
communicable diseases, including cardiovascular and brain pathologies. This …

The Neurovascular Unit (NVU) is an important multicellular structure of the central nervous
system (CNS), which participates in the regulation of cerebral blood flow (CBF), delivery of …