Metagenomics poses opportunities for clinical and public health virology applications by
offering a way to assess complete taxonomic composition of a clinical sample in an …

Background The widespread use of the integrase strand transfer inhibitor (INSTI)
dolutegravir in first-line and second-line antiretroviral therapy (ART) might facilitate …

We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred
nine individuals with this variant had a 0.54 to 0.74 log10 increase (ie, a~ 3.5-fold to 5.5-fold …

Abstract HIVACAT T-cell immunogen (HTI) is a novel human immunodeficiency virus (HIV)
vaccine immunogen designed to elicit cellular immune responses to HIV targets associated …

Emerging infectious diseases are one of the main threats to public health, with the potential
to cause a pandemic when the infectious agent manages to spread globally. The first major …

Viral sequence classification has wide applications in clinical, epidemiological, structural
and functional categorization studies. Most existing approaches rely on an initial alignment …

Background Regional and subtype-specific mutational patterns of HIV-1 transmitted drug
resistance (TDR) are essential for informing first-line antiretroviral (ARV) therapy guidelines …

Background The HIV pandemic is characterized by extensive genetic variability, which has
challenged the development of HIV drugs and vaccines. Although HIV genomes have been …

For many disease-causing virus species, global diversity is clustered into a taxonomy of
subtypes with clinical significance. In particular, the classification of infections among the …

The evolution of recognition specificities by the immune system depends on the generation
of receptor diversity and on connecting the binding of new antigens with the initiation of …