Leishmaniasis and Chagas disease are endemic pathologies in tropical countries. These
cause high morbidity and a public health problem. Current chemotherapies are based on …

Heterocyclic N-oxides have emerged as promising agents against a number of diseases
and disorders, especially infectious diseases. This review analyzes the emergence and …

Despite the tremendous improvement in overall global health heralded by the adoption of
the Millennium Declaration in the year 2000, tropical infections remain a major health …

Novel pyridine-based dihydrazones (3a-l) were synthesized by the condensation of
appropriate aldehydes and pyridine-2, 6-dicarbohydrazide (2) which was obtained by the …

African trypanosomes cause diseases in humans and livestock. Human African
trypanosomiasis is caused by Trypanosoma brucei rhodesiense and T. b. gambiense …

Tuberculosis (TB) is currently the leading cause of death related to infectious diseases
worldwide, as reported by the World Health Organization. Moreover, the increasing number …

Chagas disease affects around 8 million people worldwide and its treatment depends on
only two nitroheterocyclic drugs, benznidazole (BZD) and nifurtimox (NFX). Both drugs have …

Chagas disease, caused by the protozoan Trypanosoma cruzi, is a neglected chronic
tropical infection endemic in Latin America. New and effective treatments are urgently …

The anti-Trypanosoma cruzi activity of 5-nitro-2-furfuriliden derivatives as well as the
cytotoxicity of these compounds on J774 macrophages cell line and FN1 human fibroblast …

Neglected tropical diseases (NTD) are a group of 17 diseases transmitted by virus, protozoa,
helminthes and bacteria. These illnesses are responsible for millions of deaths per year …