Social determinants of cardiovascular disease

TM Powell-Wiley, Y Baumer, FO Baah… - Circulation …, 2022 - Am Heart Assoc
Social determinants of health (SDoH), which encompass the economic, social,
environmental, and psychosocial factors that influence health, play a significant role in the …

A review on the genetic, environmental, and lifestyle aspects of the early-life origins of cardiovascular disease

R Kelishadi, P Poursafa - Current problems in pediatric and adolescent …, 2014 - Elsevier
This article is a comprehensive review on developmental origins of health and disease
regarding various factors related to the origins of cardiovascular diseases from early life. It …

Exposure to volatile organic compounds–acrolein, 1, 3-butadiene, and crotonaldehyde–is associated with vascular dysfunction

KE McGraw, DW Riggs, S Rai, A Navas-Acien… - Environmental …, 2021 - Elsevier
Background Cardiovascular disease (CVD) is the leading cause of mortality worldwide.
Exposure to air pollution, specifically particulate matter of diameter≤ 2.5 μm (PM 2.5), is a …

Current applications of genetic risk scores to cardiovascular outcomes and subclinical phenotypes

JA Smith, EB Ware, P Middha, L Beacher… - Current epidemiology …, 2015 - Springer
Genetic risk scores are a useful tool for examining the cumulative predictive ability of genetic
variation on cardiovascular disease. Important considerations for creating genetic risk …

MicroRNAs associated with exercise and diet: a systematic review

E Flowers, GY Won, Y Fukuoka - Physiological genomics, 2015 - journals.physiology.org
MicroRNAs are posttranscriptional regulators of gene expression. MicroRNAs reflect
individual biologic adaptation to exposures in the environment. As such, measurement of …

Gene–environment interaction: A variable selection perspective

F Zhou, J Ren, X Lu, S Ma, C Wu - Epistasis: Methods and Protocols, 2021 - Springer
Gene–environment interactions have important implications for elucidating the genetic basis
of complex diseases beyond the joint function of multiple genetic factors and their …

Twelve variants polygenic score for low‐density lipoprotein cholesterol distribution in a large cohort of patients with clinically diagnosed familial hypercholesterolemia …

E Olmastroni, M Gazzotti, M Arca… - Journal of the …, 2022 - Am Heart Assoc
Background A significant proportion of individuals clinically diagnosed with familial
hypercholesterolemia (FH), but without any disease‐causing mutation, are likely to have …

Reviewing the use and quality of machine learning in developing clinical prediction models for cardiovascular disease

S Allan, R Olaiya, R Burhan - Postgraduate Medical Journal, 2022 - academic.oup.com
Cardiovascular disease (CVD) is one of the leading causes of death across the world. CVD
can lead to angina, heart attacks, heart failure, strokes, and eventually, death; among many …

Advantageous early-life environments cushion the genetic risk for ischemic heart disease

S Baker, P Biroli, H van Kippersluis… - Proceedings of the …, 2024 - pnas.org
In one of the first papers on the impact of early-life conditions on individuals' health in older
age, Barker and Osmond [Lancet, 327, 1077–1081 (1986)] show a strong positive …

Differential lipid metabolism outcomes associated with ADRB2 gene polymorphisms in response to two dietary interventions in overweight/obese subjects

O Ramos-Lopez, JI Riezu-Boj, FI Milagro, L Goni… - Nutrition, Metabolism …, 2018 - Elsevier
Background and aims A precise nutrigenetic management of hypercholesterolemia involves
the understanding of the interactions between the individual's genotype and dietary intake …