Dysbiosis in inflammatory bowel disease: pathogenic role and potential therapeutic targets

PT Santana, SLB Rosas, BE Ribeiro, Y Marinho… - International journal of …, 2022 - mdpi.com
Microbe–host communication is essential to maintain vital functions of a healthy host, and its
disruption has been associated with several diseases, including Crohn's disease and …

Genetic and epigenetic etiology of inflammatory bowel disease: An update

S Jarmakiewicz-Czaja, M Zielińska, A Sokal, R Filip - Genes, 2022 - mdpi.com
Inflammatory bowel disease (IBD) is a chronic disease with periods of exacerbation and
remission of the disease. The etiology of IBD is not fully understood. Many studies point to …

Novel fecal biomarkers that precede clinical diagnosis of ulcerative colitis

HJ Galipeau, A Caminero, W Turpin, M Bermudez-Brito… - Gastroenterology, 2021 - Elsevier
Background & Aims Altered gut microbiota composition and function have been associated
with inflammatory bowel diseases, including ulcerative colitis (UC), but the causality and …

[HTML][HTML] JAK inhibitors: A new dawn for oral therapies in inflammatory bowel diseases

C Herrera-deGuise, X Serra-Ruiz, E Lastiri… - Frontiers in …, 2023 - frontiersin.org
Inflammatory bowel disease (IBD) is a chronic immune-mediated condition of the
gastrointestinal tract that requires chronic treatment and strict surveillance. Development of …

[HTML][HTML] Human CD4+ CD8α+ Tregs induced by Faecalibacterium prausnitzii protect against intestinal inflammation

S Touch, E Godefroy, N Rolhion, C Danne, C Oeuvray… - JCI insight, 2022 - ncbi.nlm.nih.gov
Abundance of Faecalibacterium prausnitzii, a dominant bacterium of the human microbiota
that exhibits antiinflammatory effects, is decreased in patients with inflammatory bowel …

Probiotic Lactobacillus and Bifidobacterium Strains Counteract Adherent-Invasive Escherichia coli (AIEC) Virulence and Hamper IL-23/Th17 Axis in Ulcerative Colitis …

G Leccese, A Bibi, S Mazza, F Facciotti, F Caprioli… - Cells, 2020 - mdpi.com
Hypersecretion of proinflammatory cytokines and dysregulated activation of the IL-23/Th17
axis in response to intestinal microbiota dysbiosis are key factors in the pathogenesis of …

Short‐chain fatty acids affect the development of inflammatory bowel disease through intestinal barrier, immunology, and microbiota: A promising therapy?

K Peng, S Xia, S Xiao, Q Yu - Journal of gastroenterology and …, 2022 - Wiley Online Library
Intestinal metabolites are attracting increasing interest, especially more and more studies
have found they are closely related to diseases. Microbial fermentation of indigestible …

Retinoic acid, leaky gut, and autoimmune diseases

L Abdelhamid, XM Luo - Nutrients, 2018 - mdpi.com
A leaky gut has been observed in a number of autoimmune diseases including type 1
diabetes, multiple sclerosis, inflammatory bowel disease, and systemic lupus …

Immune effects of γδ T cells in colorectal cancer: a review

R Ma, D Yuan, Y Guo, R Yan, K Li - Frontiers in immunology, 2020 - frontiersin.org
Gamma delta (γδ) T cells can effectively recognize and kill colorectal cancer (CRC) cells,
thereby suppressing tumor progression via multiple mechanisms. They also have abilities to …

[HTML][HTML] Manipulation of gut microbiota as a key target for crohn's disease

R Rashed, R Valcheva, LA Dieleman - Frontiers in Medicine, 2022 - frontiersin.org
Crohn's disease (CD) is an inflammatory bowel disease (IBD) sub-type characterized by
transmural chronic inflammation of the gastrointestinal tract. Research indicates a complex …