Major reactive oxygen species (ROS)–producing systems in vascular wall include NADPH
(reduced form of nicotinamide adenine dinucleotide phosphate) oxidase, xanthine oxidase …

The arginase enzyme developed in early life forms and was maintained during evolution. As
the last step in the urea cycle, arginase cleaves l-arginine to form urea and l-ornithine. The …

The endothelium can evoke relaxations of the underlying vascular smooth muscle, by
releasing vasodilator substances. The best‐characterized endothelium‐derived relaxing …

Arginase has roots in early life-forms. It converts L-arginine to urea and ornithine. The former
provides protection against NH 3; the latter serves to stimulate cell growth and other …

The vitamin D hormone 1α, 25-dihydroxyvitamin D3 [1, 25 (OH) 2D3] is essential for the
preservation of serum calcium and phosphate levels but may also be important for the …

Functional integrity of the vascular endothelium is of fundamental importance for normal
vascular function. A key factor regulating endothelial function is the bioavailability of nitric …

Background—Endothelial dysfunction plays an important role in the early development of
atherosclerosis and vascular complications in type 2 diabetes mellitus. Increased …

Arginase is a ubiquitous enzyme in the urea cycle (UC) that hydrolyzes L‐arginine to urea
and L‐ornithine. Two mammalian arginase isoforms, arginase1 (ARG1) and arginase2 …

Vascular endothelial dysfunction precedes atherosclerosis and contributes to cardiovascular
disease (CVD), which accounts for one-third of all deaths in the United States. Chronic …

Abstract Arginase (EC 3.5. 3.1) is the bimanganese enzyme that converts L‐arginine into
ornithine and urea. This enzyme was discovered more than a century ago and early α …