Kidney stones (also known as urinary stones or nephrolithiasis) are highly prevalent,
affecting approximately 10% of adults worldwide, and the incidence of stone disease is …

Technologies such as next-generation sequencing and chromosomal microarray have
advanced the understanding of the molecular pathogenesis of a variety of renal disorders …

INTRODUCTION Kidney stone disease affects 1 in 10 persons at least once per life-time
worldwide, in 2% the disease is recurrent. For the individual stone disease can be painful …

The identification of genes causing inherited kidney diseases yielded crucial insights in the
molecular basis of disease and improved our understanding of physiological processes that …

The identification of genetic factors associated with the risk, onset, and progression of kidney
disease has the potential to provide mechanistic insights and therapeutic perspectives. In …

Although often considered a single-entity, chronic kidney disease (CKD) comprises many
pathophysiologically distinct disorders that result in persistently abnormal kidney structure …

Rationale & Objective Chronic kidney disease (CKD) has a heritable component. We aimed
to quantify familial aggregation of CKD in the general population and assess the extent to …

Abstract Purpose of Review To provide a comprehensive update on the role of genetic
testing for the evaluation of kidney transplant recipient and living donor candidates. Recent …

Abstract Magnesium (Mg 2+) homeostasis is critical for metabolism. However, the genetic
determinants of the renal handling of Mg 2+, which is crucial for Mg 2+ homeostasis, and the …

Uromodulin, the most abundant protein in normal urine, is produced by cells lining the thick
ascending limb (TAL) of the loop of Henle. Uromodulin regulates the activity of the …