TWIST1+FAP+ fibroblasts in the pathogenesis of intestinal fibrosis in Crohn's disease
Y Zhang, J Wang, H Sun, Z Xun, Z He, Y Zhao… - The Journal of Clinical …, 2024 - jci.org
Intestinal fibrosis, a severe complication of Crohn's disease (CD), is characterized by
excessive extracellular matrix (ECM) deposition and induces intestinal strictures, but there …
excessive extracellular matrix (ECM) deposition and induces intestinal strictures, but there …
[HTML][HTML] Drug targets regulate systemic metabolism and provide new horizons to treat nonalcoholic steatohepatitis
Y Wang, H Yu, Z Cen, Y Zhu, W Wu - Metabolism Open, 2023 - Elsevier
Nonalcoholic steatohepatitis (NASH), is the advanced stage of non-alcoholic fatty liver
disease (NAFLD) with rapidly rising global prevalence. It is featured with severe hepatocyte …
disease (NAFLD) with rapidly rising global prevalence. It is featured with severe hepatocyte …
Increased tropism of extracellular vesicles derived from palmitic acid-treated hepatocytes to activated hepatic stellate cells
M Yamaguchi, T Kanazawa, S Morino, S Iioka… - Membranes, 2022 - mdpi.com
Myofibroblast-like activated hepatic stellate cells (aHSCs), which produce collagen, a major
cause of liver fibrosis, are specific target cells for antifibrotic treatment. Recently, several …
cause of liver fibrosis, are specific target cells for antifibrotic treatment. Recently, several …
Harmine inhibits pulmonary fibrosis through regulating DNA damage repair-related genes and activation of TP53-Gadd45α pathway
Y Gong, J Wang, M Pan, Y Zhao, H Zhang… - International …, 2024 - Elsevier
Background Harmine has many pharmacological activities and has been found to
significantly inhibit the fibrosis of keloid fibroblasts. DNA damage repair (DDR) is essential to …
significantly inhibit the fibrosis of keloid fibroblasts. DNA damage repair (DDR) is essential to …
Expression of IRAK1 in Hepatocellular Carcinoma, Its Clinical Significance, and Docking Characteristics with Selected Natural Compounds
C Song, X Gu, R Li - Current Oncology, 2022 - mdpi.com
This study aimed to explore clinical significance of interleukin-1 receptor-associated kinase
1 (IRAK1) in the diagnosis, prognosis, and targeted therapy of hepatocellular carcinoma. A …
1 (IRAK1) in the diagnosis, prognosis, and targeted therapy of hepatocellular carcinoma. A …
Development of a Collagen Assay and testing pro-and antifibrotic compounds on fibroblasts in vitro
R Bosma - 2023 - fse.studenttheses.ub.rug.nl
Collagen is the most abundant protein found in mammals, making up to 30% of the total
protein content. Disruption of collagen homeostasis can lead to diseases like liver fibrosis …
protein content. Disruption of collagen homeostasis can lead to diseases like liver fibrosis …