Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
Genetic influences on psychiatric disorders transcend diagnostic boundaries, suggesting
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
substantial pleiotropy of contributing loci. However, the nature and mechanisms of these …
Identification of shared and differentiating genetic architecture for autism spectrum disorder, attention-deficit hyperactivity disorder and case subgroups
Attention-deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
highly heritable neurodevelopmental conditions, with considerable overlap in their genetic …
Descriptive, predictive and explanatory personality research: Different goals, different approaches, but a shared need to move beyond the Big Few traits
We argue that it is useful to distinguish between three key goals of personality science—
description, prediction and explanation—and that attaining them often requires different …
description, prediction and explanation—and that attaining them often requires different …
Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing
Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
driven by genetics. To identify LOAD risk loci, we performed a large genome-wide …
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
We expanded GWAS discovery for type 2 diabetes (T2D) by combining data from 898,130
European-descent individuals (9% cases), after imputation to high-density reference panels …
European-descent individuals (9% cases), after imputation to high-density reference panels …
Identification of 38 novel loci for systemic lupus erythematosus and genetic heterogeneity between ancestral groups
Systemic lupus erythematosus (SLE), a worldwide autoimmune disease with high
heritability, shows differences in prevalence, severity and age of onset among different …
heritability, shows differences in prevalence, severity and age of onset among different …
Genome-wide association study of alcohol consumption and use disorder in 274,424 individuals from multiple populations
Alcohol consumption level and alcohol use disorder (AUD) diagnosis are moderately
heritable traits. We conduct genome-wide association studies of these traits using …
heritable traits. We conduct genome-wide association studies of these traits using …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects
With the increasing availability of large-scale GWAS summary data on various complex traits
and diseases, there have been tremendous interests in applications of Mendelian …
and diseases, there have been tremendous interests in applications of Mendelian …
Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder
Attention deficit/hyperactivity disorder (ADHD) is a highly heritable childhood behavioral
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …
disorder affecting 5% of children and 2.5% of adults. Common genetic variants contribute …