The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust
common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 …

Epilepsy is a highly heritable disorder affecting over 50 million people worldwide, of which
about one-third are resistant to current treatments. Here we report a multi-ancestry genome …

Reading and writing are crucial life skills but roughly one in ten children are affected by
dyslexia, which can persist into adulthood. Family studies of dyslexia suggest heritability up …

Chronic low-grade inflammation is linked to a multitude of chronic diseases. We report the
largest genome-wide association study (GWAS) on C-reactive protein (CRP), a marker of …

Background Suicide is a leading cause of death worldwide, and nonfatal suicide attempts,
which occur far more frequently, are a major source of disability and social and economic …

The Psychiatric Genomics Consortium (PGC) is the largest consortium in the history of
psychiatry. This global effort is dedicated to rapid progress and open science, and in the …

Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …

Obesity is a risk factor for a wide variety of health problems. In a genome-wide association
study (GWAS) of body mass index (BMI) in Japanese people (n= 173,430), we found 85 loci …

Physical activity and sleep duration are established risk factors for many diseases, but their
aetiology is poorly understood, partly due to relying on self-reported evidence. Here we …

For over a century, psychiatric disorders have been defined by expert opinion and clinical
observation. The modern DSM has relied on a consensus of experts to define categorical …