[HTML][HTML] Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances

C Ning, Y Jiao, J Wang, W Li, J Zhou, YC Lee… - Food Science and …, 2022 - Elsevier
Diabetes has become a global concern at present, among which type 2 diabetes mellitus
(T2DM) accounts for approximately 90%–95% of patients. T2DM is a type of metabolic …

Heterocyclic compounds as a magic bullet for diabetes mellitus: a review

U Farwa, MA Raza - RSC advances, 2022 - pubs.rsc.org
Diabetes mellitus (DM) is a major metabolic disorder due to hyperglycemia, which is
increasing all over the world. From the last two decades, the use of synthetic agents has …

Molecular Docking and Simulation Studies of Antidiabetic Agents Devised from Hypoglycemic Polypeptide‐P of Momordica charantia

R Arif, S Ahmad, G Mustafa, HS Mahrosh… - BioMed research …, 2021 - Wiley Online Library
Diabetes mellitus termed as metabolic disorder is a collection of interlinked diseases and
mainly body's inability to manage glucose level which leads to cardiovascular diseases …

Antistress and anti-aging activities of Caenorhabditis elegans were enhanced by Momordica saponin extract

C Lin, Y Chen, Y Lin, X Wang, L Hu, Y Cao… - European journal of …, 2021 - Springer
Background Momordica saponin extract (MSE) was found to not only improve longevity and
neuroprotection but also alleviate fat accumulation in Caenorhabditis elegans in our …

Therapeutic Investigation of Standardized Aqueous Methanolic Extract of Bitter Melon (Momordica charantia L.) for Its Potential against Polycystic Ovarian Syndrome in Experimental …

L Hussain, N Aamir, M Hussain, M Asif… - Evidence‐Based …, 2022 - Wiley Online Library
Polycystic ovarian syndrome (PCOS) is an heterogenous, endocrine, metabolic, and
multidisciplinary disorder of reproductive‐aged females that aggravates insulin resistance …

Cytotoxicity and maternal toxicity attributed to exposure to Momordica charantia L. (Cucurbitaceae) dry leaf extract

AL Trautenmuller, J de Almeida Soares… - Journal of Toxicology …, 2023 - Taylor & Francis
ABSTRACT Momordica charantia L.(Cucurbitaceae), popularly known as “bitter melon” or
“bitter gourd,” is a climbing plant well-adapted to tropical countries. This plant is used …

Comprehensive computational studies of naturally occurring kuguacins as antidiabetic agents by targeting visfatin

SO Famuyiwa, S Ahmad, EG Fakola, AJ Olusola… - Chemistry Africa, 2023 - Springer
Diabetes mellitus continues to be a major health concern for the global population.
Targeting visfatin has been identified as a possible channel to manage the disease …

Cymbopogon citratus (DC.) Stapf mitigates ER-stress induced by streptozotocin in rats via down-regulation of GRP78 and up-regulation of Nrf2 signaling

OO Elekofehinti, AT Onunkun, TM Olaleye - Journal of ethnopharmacology, 2020 - Elsevier
Ethnopharmacological relevance Endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes mellitus, contributing to pancreatic dysfunction and insulin …

Antihyperglycaemia and related gene expressions of aqueous extract of Gongronema latifolium leaf in alloxan-induced diabetic rats

BO Ajiboye, BE Oyinloye, PE Agboinghale… - Pharmaceutical …, 2019 - Taylor & Francis
Abstract Context: Gongronema latifolium Benth (Asclepiadaceae) has been highly utilized in
controlling diabetes mellitus traditionally in the eastern part of Nigeria. Objectives …

Momordica charantia nanoparticles potentiate insulin release and modulate antioxidant gene expression in pancreas of diabetic rats

OO Elekofehinti - Egyptian Journal of Medical Human Genetics, 2022 - Springer
Background Green synthesis of nanoparticles with medicinal plants has inherent potential in
the management of diabetes mellitus. This study synthesized Momordica charantia …