Human genetic and immunological determinants of critical COVID-19 pneumonia
Q Zhang, P Bastard, A Cobat, JL Casanova - Nature, 2022 - nature.com
SARS-CoV-2 infection is benign in most individuals but, in around 10% of cases, it triggers
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
hypoxaemic COVID-19 pneumonia, which leads to critical illness in around 3% of cases …
Mucosal immune responses to infection and vaccination in the respiratory tract
The lungs are constantly exposed to inhaled debris, allergens, pollutants, commensal or
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
pathogenic microorganisms, and respiratory viruses. As a result, innate and adaptive …
Sensing of SARS-CoV-2 by pDCs and their subsequent production of IFN-I contribute to macrophage-induced cytokine storm during COVID-19
Lung-infiltrating macrophages create a marked inflammatory milieu in a subset of patients
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …
with COVID-19 by producing a cytokine storm, which correlates with increased lethality …
Pathogenesis of respiratory viral and fungal coinfections
Individuals suffering from severe viral respiratory tract infections have recently emerged as
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
“at risk” groups for developing invasive fungal infections. Influenza virus is one of the most …
Transitional dendritic cells are distinct from conventional DC2 precursors and mediate proinflammatory antiviral responses
FB Sulczewski, RA Maqueda-Alfaro… - Nature …, 2023 - nature.com
High-dimensional approaches have revealed heterogeneity amongst dendritic cells (DCs),
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …
including a population of transitional DCs (tDCs) in mice and humans. However, the origin …
The pathogenesis of coronavirus-19 disease
AC Borczuk, RK Yantiss - Journal of biomedical science, 2022 - Springer
Severe acute respiratory syndrome-associated coronavirus-2 (SARS-CoV-2) is the causal
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …
agent of coronavirus disease-2019 (COVID-19), a systemic illness characterized by variably …
Type I interferons and SARS-CoV-2: from cells to organisms
Type I interferons (IFNs) have broad and potent antiviral activity. We review the interplay
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
between type I IFNs and SARS-CoV-2. Human cells infected with SARS-CoV-2 in vitro …
Interferon induction, evasion, and paradoxical roles during SARS‐CoV‐2 infection
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), the causative agent of
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
coronavirus disease 2019 (COVID‐19), has caused millions of deaths in the past two years …
TLR2 and TLR7 mediate distinct immunopathological and antiviral plasmacytoid dendritic cell responses to SARS‐CoV‐2 infection
RM van der Sluis, LB Cham, A Gris‐Oliver… - The EMBO …, 2022 - embopress.org
Understanding the molecular pathways driving the acute antiviral and inflammatory
response to SARS‐CoV‐2 infection is critical for developing treatments for severe COVID …
response to SARS‐CoV‐2 infection is critical for developing treatments for severe COVID …
Severe COVID-19 patients have impaired plasmacytoid dendritic cell-mediated control of SARS-CoV-2
M Venet, MS Ribeiro, E Décembre, A Bellomo… - Nature …, 2023 - nature.com
Type I and III interferons (IFN-I/λ) are important antiviral mediators against SARS-CoV-2
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …
infection. Here, we demonstrate that plasmacytoid dendritic cells (pDC) are the predominant …