[HTML][HTML] SARS-CoV-2 accessory proteins in viral pathogenesis: knowns and unknowns

N Redondo, S Zaldívar-López, JJ Garrido… - Frontiers in …, 2021 - frontiersin.org
There are still many unanswered questions concerning viral SARS-CoV-2 pathogenesis in
COVID-19. Accessory proteins in SARS-CoV-2 consist of eleven viral proteins whose roles …

[HTML][HTML] SARS-CoV-2-specific immune response and the pathogenesis of COVID-19

E Gusev, A Sarapultsev, L Solomatina… - International journal of …, 2022 - mdpi.com
The review aims to consolidate research findings on the molecular mechanisms and
virulence and pathogenicity characteristics of coronavirus disease (COVID-19) causative …

[HTML][HTML] Effectiveness of curcumin on outcomes of hospitalized COVID-19 patients: A systematic review of clinical trials

A Vahedian-Azimi, M Abbasifard, F Rahimi-Bashar… - Nutrients, 2022 - mdpi.com
Despite the ongoing vaccination efforts, there is still an urgent need for safe and effective
treatments to help curb the debilitating effects of COVID-19 disease. This systematic review …

[HTML][HTML] Transcriptional reprogramming from innate immune functions to a pro-thrombotic signature by monocytes in COVID-19

AK Maher, KL Burnham, EM Jones, MMH Tan… - Nature …, 2022 - nature.com
Although alterations in myeloid cells have been observed in COVID-19, the specific
underlying mechanisms are not completely understood. Here, we examine the function of …

[HTML][HTML] Pulmonary fibrosis as a result of acute lung inflammation: molecular mechanisms, relevant in vivo models, prognostic and therapeutic approaches

IA Savin, MA Zenkova, AV Sen'kova - International Journal of Molecular …, 2022 - mdpi.com
Pulmonary fibrosis is a chronic progressive lung disease that steadily leads to lung
architecture disruption and respiratory failure. The development of pulmonary fibrosis is …

[HTML][HTML] Prospective roles of tumor necrosis factor-alpha (TNF-α) in COVID-19: prognosis, therapeutic and management

Z Mohd Zawawi, J Kalyanasundram… - International journal of …, 2023 - mdpi.com
The coronavirus disease 2019 (COVID-19) became a worldwide concern at the beginning of
2020 and has affected millions. Several previous studies revealed the impact of the …

[HTML][HTML] Dexamethasone attenuates interferon-related cytokine hyperresponsiveness in COVID-19 patients

JJ Engel, CI van der Made, N Keur… - Frontiers in …, 2023 - frontiersin.org
Background Dexamethasone improves the survival of COVID-19 patients in need of
supplemental oxygen therapy. Although its broad immunosuppressive effects are well …

[HTML][HTML] Adipose tissue in COVID-19: detection of SARS-CoV-2 in adipocytes and activation of the interferon-alpha response

A Basolo, AM Poma, D Bonuccelli, A Proietti… - Journal of …, 2022 - Springer
Objective Obesity is a recognized risk factor for the progression to severe forms of COVID-
19, yet the mechanisms of the association are unclear. Methods Subcutaneous abdominal …

[HTML][HTML] Efficacy and mechanisms of traditional Chinese medicine for COVID-19: a systematic review

X Kang, D Jin, L Jiang, Y Zhang, Y Zhang, X An… - Chinese medicine, 2022 - Springer
Since the outbreak of coronavirus disease 2019 (COVID-19), traditional Chinese medicine
(TCM) has made an important contribution to the prevention and control of the epidemic …

[HTML][HTML] COVID-19 causes ferroptosis and oxidative stress in human endothelial cells

SS Jankauskas, U Kansakar, C Sardu, F Varzideh… - Antioxidants, 2023 - mdpi.com
Oxidative stress and endothelial dysfunction have been shown to play crucial roles in the
pathophysiology of COVID-19 (coronavirus disease 2019). On these grounds, we sought to …