Src is a non‐receptor cytoplasmic tyrosine kinase which becomes activated following the
stimulation of plasma membrane receptors including receptor tyrosine kinases and integrins …

Abstract FOXM1 (Forkhead box M1) is a typical proliferation-associated transcription factor,
which stimulates cell proliferation and exhibits a proliferation-specific expression pattern …

Lung cancer is the major cancer killer worldwide, and 5-yr survival is extremely poor (≤
15%), accentuating the need for more effective therapeutic strategies. Significant advances …

The Ras proto-oncogene mediates a wide variety of cellular events and is frequently
mutated in cancer. MicroRNAs (miRNAs) may regulate the development of cancer through …

Introduction: RAS mutations are common in thyroid tumors and confer a high risk of cancer
when detected in fine-needle aspiration (FNA) specimens. Specific characteristics of RAS …

Mounting evidence suggests a role for matrix metalloproteinase (MMP)-2 in the malignant
progression of breast cancer cells. We showed previously that H-Ras, but not N-Ras …

Mutation in RAS proteins is one of the most common genetic alterations observed in human
and experimentally induced rodent cancers. In vivo, oncogenic mutations have been shown …

Small cell lung cancer (SCLC) is an aggressive form of lung cancer, which represents 13%
of all cases and is strongly associated with cigarette smoking. The survival of SCLC patients …

Growing evidence indicates that the alteration of microRNA (miRNA) expression in tumors
that is induced by chemical carcinogens plays an important role in tumor development and …

The RAS family of proteins is among the most frequently mutated genes in human
malignancies. In ovarian cancer (OC), the most lethal gynecological malignancy, RAS …