Mechanism of epithelial‐mesenchymal transition in cancer and its regulation by natural compounds

HL Ang, CD Mohan, MK Shanmugam… - Medicinal research …, 2023 - Wiley Online Library
Epithelial‐mesenchymal transition (EMT) is a complex process with a primordial role in
cellular transformation whereby an epithelial cell transforms and acquires a mesenchymal …

Understanding chronic venous disease: a critical overview of its pathophysiology and medical management

MA Ortega, O Fraile-Martínez… - Journal of clinical …, 2021 - mdpi.com
Chronic venous disease (CVD) is a multifactorial condition affecting an important
percentage of the global population. It ranges from mild clinical signs, such as …

Epigenetic signatures underlying inflammation: An interplay of nutrition, physical activity, metabolic diseases, and environmental factors for personalized nutrition

O Ramos-Lopez, FI Milagro, JI Riezu-Boj… - Inflammation …, 2021 - Springer
Aim and objective Emerging translational evidence suggests that epigenetic alterations
(DNA methylation, miRNA expression, and histone modifications) occur after external stimuli …

Salivary biomarkers: novel noninvasive tools to diagnose chronic inflammation

P Dongiovanni, M Meroni, S Casati, R Goldoni… - International journal of …, 2023 - nature.com
Several chronic disorders including type 2 diabetes (T2D), obesity, heart disease and
cancer are preceded by a state of chronic low-grade inflammation. Biomarkers for the early …

Molecular mechanisms of action of hesperidin in cancer: Recent trends and advancements

V Aggarwal, HS Tuli, F Thakral… - Experimental …, 2020 - journals.sagepub.com
Hesperidin belongs to flavanones class of flavonoids and is known to possess broad-
spectrum applicability to prevent dreadful diseases such as cardiovascular disease …

The multifaceted role of curcumin in cancer prevention and treatment

MK Shanmugam, G Rane, MM Kanchi, F Arfuso… - Molecules, 2015 - mdpi.com
Despite significant advances in treatment modalities over the last decade, neither the
incidence of the disease nor the mortality due to cancer has altered in the last thirty years …

Potential role of natural compounds as anti-angiogenic agents in cancer

MK Shanmugam, S Warrier, AP Kumar… - Current vascular …, 2017 - ingentaconnect.com
Background: Neovascularization, also known as angiogenesis, is the process of capillary
sprouting from pre-existing blood vessels. This physiological process is a hallmark event in …

Innate immune programing by endotoxin and its pathological consequences

MC Morris, EA Gilliam, L Li - Frontiers in immunology, 2015 - frontiersin.org
Monocytes and macrophages play pivotal roles in inflammation and homeostasis. Recent
studies suggest that dynamic programing of macrophages and monocytes may give rise to …

Neighborhood characteristics influence DNA methylation of genes involved in stress response and inflammation: The Multi-Ethnic Study of Atherosclerosis

JA Smith, W Zhao, X Wang, SM Ratliff, B Mukherjee… - Epigenetics, 2017 - Taylor & Francis
Living in a disadvantaged neighborhood is associated with poor health outcomes even after
accounting for individual-level socioeconomic factors. The chronic stress of unfavorable …

Melatonin reduces inflammatory response in human intestinal epithelial cells stimulated by interleukin‐1β

G Mannino, F Caradonna, I Cruciata… - Journal of pineal …, 2019 - Wiley Online Library
Melatonin is the main secretory product of the pineal gland, and it is involved in the
regulation of periodic events. A melatonin production independent of the photoperiod is …