Adverse drug event detection using natural language processing: A scoping review of supervised learning methods

RM Murphy, JE Klopotowska, NF de Keizer, KJ Jager… - Plos one, 2023 - journals.plos.org
To reduce adverse drug events (ADEs), hospitals need a system to support them in
monitoring ADE occurrence routinely, rapidly, and at scale. Natural language processing …

The transporter-mediated cellular uptake and efflux of pharmaceutical drugs and biotechnology products: how and why phospholipid bilayer transport is negligible in …

DB Kell - Molecules, 2021 - mdpi.com
Over the years, my colleagues and I have come to realise that the likelihood of
pharmaceutical drugs being able to diffuse through whatever unhindered phospholipid …

Global distribution of functionally important CYP2C9 alleles and their inferred metabolic consequences

Y Zhou, L Nevosadová, E Eliasson, VM Lauschke - Human genomics, 2023 - Springer
Background Genetic variability in the cytochrome P450 CYP2C9 constitutes an important
predictor for efficacy and safety of various commonly prescribed drugs, including coumarin …

Adverse drug reactions and associated patient characteristics in older community-dwelling adults: a 6-year prospective cohort study

AS Doherty, F Boland, F Moriarty, T Fahey… - British Journal of General …, 2023 - bjgp.org
Background To date, research on adverse drug reactions (ADRs) has focused on secondary
care, and there is a paucity of studies that have prospectively examined ADRs affecting …

Incidence and patterns of adverse drug reactions among adult patients hospitalized in the University of Gondar comprehensive specialized hospital: A prospective …

AK Sendekie, AK Netere, S Tesfaye, EM Dagnew… - PLoS …, 2023 - journals.plos.org
Background Adverse drug reactions (ADRs) have continued to be a public health challenge
with significant clinical and healthcare costs. However, little is known regarding the …

Pharmacological interactions of nintedanib and pirfenidone in patients with idiopathic pulmonary fibrosis in times of COVID-19 pandemic

JM Serra López-Matencio, M Gómez… - Pharmaceuticals, 2021 - mdpi.com
The discovery of antifibrotic agents have resulted in advances in the therapeutic
management of idiopathic pulmonary fibrosis (IPF). Currently, nintedanib and pirfenidone …

Medication review and deprescribing in different healthcare settings: a position statement from an Italian scientific consortium

M Carollo, V Boccardi, S Crisafulli, V Conti… - Aging Clinical and …, 2024 - Springer
Recent medical advancements have increased life expectancy, leading to a surge in
patients affected by multiple chronic diseases and consequent polypharmacy, especially …

The INGENIOUS trial: Impact of pharmacogenetic testing on adverse events in a pragmatic clinical trial

MT Eadon, MB Rosenman, P Zhang… - The …, 2023 - nature.com
Adverse drug events (ADEs) account for a significant mortality, morbidity, and cost burden.
Pharmacogenetic testing has the potential to reduce ADEs and inefficacy. The objective of …

Teaching rational prescribing in undergraduate medical education: a systematic search and review

Iİ Budakoğlu, Ö Coşkun, YS Kıyak… - European journal of clinical …, 2023 - Springer
Aim This study aimed to reveal the current status of the literature on rational prescribing
training in undergraduate medical education. Methods This study followed the preferred …

The occurrence of drug-induced side effects in women and men with arterial hypertension and comorbidities

M Polaczyk, A Olszanecka… - Polish Heart …, 2022 - journals.viamedica.pl
Background: Women have been underrepresented in large clinical trials in hypertension,
and the incidence of adverse drug reactions by sex has been not sufficiently described …