Klotho is a critical protein that protects the kidney. Klotho is severely downregulated in
chronic kidney disease (CKD), and its deficiency is implicated in the pathogenesis and …

Proteolysis-targeting chimera (PROTAC) and other targeted protein degradation (TPD)
molecules that induce degradation by the ubiquitin-proteasome system (UPS) offer new …

Background Tripartite motif (TRIM) family proteins have more than 80 members and are
widely found in various eukaryotic cells. Most TRIM family proteins participate in the …

The S-phase checkpoint involving CHK1 is essential for fork stability in response to fork
stalling. PARP1 acts as a sensor of replication stress and is required for CHK1 activation …

Oxaliplatin is a widely used chemotherapy drug for patients with advanced colorectal cancer
(CRC); however, frequent drug resistance limits its therapeutic efficacy in patients. Here, this …

Background Degrons are short linear motifs, bound by E3 ubiquitin ligase to target protein
substrates to be degraded by the ubiquitin-proteasome system. Mutations leading to …

How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …

Abstract Tripartite motif-containing 44 (TRIM44) has recently been implicated in various
pathological processes in numerous cancers, including lung adenocarcinoma (LUAD); …

Abstract Background Nuclear Yes1‐associated transcriptional regulator (YAP1) promotes
tumor progression. However, the function of cytoplasmic YAP1 in breast cancer cells and its …

Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to
eliminate previously undruggable proteins by repurposing the cell's endogenous protein …