Targeted protein degradation (TPD) has rapidly emerged as a therapeutic modality to
eliminate previously undruggable proteins by repurposing the cell's endogenous protein …

Abstract Tripartite motif-containing 44 (TRIM44) has recently been implicated in various
pathological processes in numerous cancers, including lung adenocarcinoma (LUAD); …

The E3 ubiquitin ligase 3-hydroxy-3-methylglutaryl reductase degradation (HRD1) was
found to be a tumor suppressor in diverse types of cancers; we aimed to explore its …

Despite the availability of various therapeutic classes of antihypertensive drugs,
hypertension remains poorly controlled, in part because of poor adherence. Hence, there is …

Introduction Excessive immune activation induces tissue damage during infection.
Compared to external strategies to reconstruct immune homeostasis, host balancing ways …

OTUD5 (OTU Deubiquitinase 5) is a functional cysteine protease with deubiquitinase activity
and is a member of the ovarian tumor protease (OTU) family. OTUD5 is involved in the …

Protein ubiquitination regulates a wide range of cellular processes. The degree of protein
ubiquitination is determined by the delicate balance between ubiquitin ligase (E3)-mediated …

Effective treatment for metastasis, a leading cause of cancer‐associated death, is still
lacking. To seed on a distal organ, disseminated cancer cells (DCCs) must adapt to the local …

Chromatin remodeler ARID1A regulates gene transcription by modulating nucleosome
positioning and chromatin accessibility. While ARID1A-mediated stage and lineage …

Aggravated endoplasmic reticulum stress (ERS) and apoptosis in podocytes play an
important role in lupus nephritis (LN) progression, but its mechanism is still unclear. Herein …