The role of hypoxia-regulated long non-coding RNA (lncRNA) in the development of head
and neck squamous cell carcinoma (HNSCC) remains to be elucidated. In the current study …

Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, with a high incidence in squamous epithelium. The E3 ubiquitin ligase DTL is a …

Ischemic stroke is a major global health issue. Ischemia and subsequent reperfusion results
in stroke‐related brain injury. Previous studies have demonstrated that nuclear‐enriched …

Acute myeloid leukemia is a heterogeneous hematologic malignancy with high mortality in
the world. NPM1 gene mutations are a frequent occurrence in acute myeloid leukemia …

Purpose Oxidative stress-induced apoptosis of lens epithelial cells (LECs) contributes to the
pathogenesis of age-related cataract (ARC). The purpose of this research is to underlie the …

Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer.
Accumulating evidence indicates that non-alcoholic steatohepatitis (NASH) is a key …

E3 ubiquitin ligases (E3s) and deubiquitinating enzymes (DUBs) play key roles in protein
degradation. However, a large number of E3 substrate interactions (ESIs) and DUB …

Abstract Type I interferon (IFN-I) exhibits broad-spectrum antiviral properties and is
commonly employed in clinical for the treatment of viral infections. In this study, we unveil …

Despite recent advances in cancer immunotherapy, their efficacy for treating patients with
prostate adenocarcinoma (PRAD) is low due to complex immune evasion mechanisms …

Hepatocellular carcinoma (HCC) is a prevalent malignancy characterized by complex
heterogeneity and drug resistance. Resistance to ferroptosis is closely related to the …