Epstein-Barr virus suppresses N6-methyladenosine modification of TLR9 to promote immune evasion
X Zhang, Z Li, Q Peng, C Liu, Y Wu, Y Wen… - Journal of Biological …, 2024 - ASBMB
Epstein-Barr virus (EBV) is a human tumor virus associated with a variety of malignancies,
including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas. N 6 …
including nasopharyngeal carcinoma, gastric cancers, and B-cell lymphomas. N 6 …
The 2023 Lewis K. Dahl Memorial Lecture: Angiotensin-Converting Enzyme 2 Posttranslational Modifications—Implications for Hypertension and SARS-CoV-2 …
M Elgazzaz, C Filipeanu, E Lazartigues - Hypertension, 2024 - Am Heart Assoc
ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well
recognized as an important member of the (RAS) renin–angiotensin system with important …
recognized as an important member of the (RAS) renin–angiotensin system with important …
Bioinformatics and experimental analyses reveal MAP4K4 as a potential Marker for gastric cancer
J Zhang, X Cai, W Cui, Z Wei - Genes, 2022 - mdpi.com
Background: Gastric cancer remains the most prevalent and highly lethal disease
worldwide. MAP4K4, a member of Ste20, plays an important role in various pathologies …
worldwide. MAP4K4, a member of Ste20, plays an important role in various pathologies …
[HTML][HTML] PPDPF promotes the progression and acts as an antiapoptotic protein in non-small cell lung cancer
M Yun, L Yingzi, G Jie, L Guanxin, Z Zimei… - … Journal of Biological …, 2022 - ncbi.nlm.nih.gov
Resistance to radiotherapy is frequently observed in the clinic and leads to poor prognosis
of non-small cell lung cancer (NSCLC). How to overcome resistance to radiotherapy is a …
of non-small cell lung cancer (NSCLC). How to overcome resistance to radiotherapy is a …
[HTML][HTML] SMURF2 facilitates ubiquitin-mediated degradation of ID2 to attenuate lung cancer cell proliferation
M Han, Y Guo, Y Li, Q Zeng, W Zhu… - International Journal of …, 2023 - ncbi.nlm.nih.gov
SMAD-specific E3 ubiquitin protein ligase 2 (SMURF2) functions as either a tumor promoter
or tumor suppressor in several tumors. However, the detailed effect of SMURF2 on non …
or tumor suppressor in several tumors. However, the detailed effect of SMURF2 on non …
DTL promotes head and neck squamous cell carcinoma progression by mediating the degradation of ARGLU1 to regulate the Notch signaling pathway
J Shi, X Yu, G Li, X Zhao, J Chen, Y Fang… - International Journal of …, 2024 - Elsevier
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer
worldwide, with a high incidence in squamous epithelium. The E3 ubiquitin ligase DTL is a …
worldwide, with a high incidence in squamous epithelium. The E3 ubiquitin ligase DTL is a …
UCHL1 contributes to insensitivity to endocrine therapy in triple-negative breast cancer by deubiquitinating and stabilizing KLF5
J Li, Y Liang, S Zhou, J Chen, C Wu - Breast Cancer Research, 2024 - Springer
Background Ubiquitin carboxyl-terminal hydrolase L1 (UCHL1) is a deubiquitinating enzyme
that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore …
that regulates ERα expression in triple-negative cancer (TNBC). This study aimed to explore …
MARCH5-mediated downregulation of ACC2 promotes fatty acid oxidation and tumor progression in ovarian cancer
S Zhao, Q Wang, X Zhang, B Ma, Y Shi, Y Yin… - Free Radical Biology …, 2024 - Elsevier
Lipid metabolic reprogramming has been recognized as a hallmark of human cancer. Acetyl-
CoA Carboxylases (ACCs) are key rate-limiting enzymes involved in fatty acid metabolism …
CoA Carboxylases (ACCs) are key rate-limiting enzymes involved in fatty acid metabolism …
[HTML][HTML] New approaches targeting the renin-angiotensin system: inhibition of brain aminopeptidase A, ACE2 ubiquitination, and angiotensinogen
E Lazartigues, C Llorens-Cortes, AHJ Danser - Canadian Journal of …, 2023 - Elsevier
Despite the availability of various therapeutic classes of antihypertensive drugs,
hypertension remains poorly controlled, in part due to poor adherence. Hence, there is a …
hypertension remains poorly controlled, in part due to poor adherence. Hence, there is a …
Targeting deubiquitinase OTUB1 protects vascular smooth muscle cells in atherosclerosis by modulating PDGFRβ
F Xu, H Chen, C Zhou, T Zang, R Wang, S Shen… - Frontiers of …, 2024 - Springer
Atherosclerosis is a chronic artery disease that causes various types of cardiovascular
dysfunction. Vascular smooth muscle cells (VSMCs), the main components of atherosclerotic …
dysfunction. Vascular smooth muscle cells (VSMCs), the main components of atherosclerotic …