Atherosclerosis is a chronic artery disease that causes various types of cardiovascular
dysfunction. Vascular smooth muscle cells (VSMCs), the main components of atherosclerotic …

ACE2 (angiotensin-converting enzyme 2), a multifunctional transmembrane protein, is well
recognized as an important member of the (RAS) renin–angiotensin system with important …

FBXO protein family plays an essential role in the ubiquitination process acting as E3
ligases, which may contribute to the progression of cancers. However, the molecular …

The growing interest in post-translational protein modification, particularly in SUMOylation, is
driven by its crucial role in cell cycle regulation. SUMOylation affects various cell cycle …

Clinical research indicates that SARS-CoV-2 infection is linked to several neurological
consequences, and the virus is still spreading despite the availability of vaccinations and …

Resistance to radiotherapy is frequently observed in the clinic and leads to poor prognosis
of non-small cell lung cancer (NSCLC). How to overcome resistance to radiotherapy is a …

Introduction: Ubiquitination is involved in many biological processes and its predictive value
for prognosis in cervical cancer is still unclear. Methods: To further explore the predictive …

Multiple myeloma (MM) is regarded as a hematological malignancy and it is challenging to
cure, largely caused by the increased risk of relapse or the emergence of resistance to the …

Background Stage IV gastric cancer is a highly heterogeneous and lethal tumor with few
therapeutic strategies. The combination of programmed cell death protein 1 inhibitors and …

Simple Summary Dynamic O-GlcNAc modification regulates the functions of proteins in a
broad range of cellular processes. Dysregulation of the sole enzymes responsible for O …