[HTML][HTML] New drug treatments for schizophrenia: a review of approaches to target circuit dysfunction
OD Howes, E Dawkins, MC Lobo, SJ Kaar, K Beck - Biological Psychiatry, 2024 - Elsevier
Schizophrenia is a leading cause of global disease burden. Current drug treatments are
associated with significant side-effects and have limited efficacy for many patients; …
associated with significant side-effects and have limited efficacy for many patients; …
Neuroreceptor Inhibition by Clozapine Triggers Mitohormesis and Metabolic Reprogramming in Human Blood Cells
K Fehsel, ML Bouvier, L Capobianco, P Lunetti, B Klein… - Cells, 2024 - mdpi.com
The antipsychotic drug clozapine demonstrates superior efficacy in treatment-resistant
schizophrenia, but its intracellular mode of action is not completely understood. Here, we …
schizophrenia, but its intracellular mode of action is not completely understood. Here, we …
Inhibition of reactive oxygen species production accompanying alternatively activated microglia by risperidone in a mouse ketamine model of schizophrenia
R Fujikawa, J Yamada, S Maeda… - Journal of …, 2024 - Wiley Online Library
Recent studies have highlighted the potential involvement of reactive oxygen species (ROS)
and microglia, a major source of ROS, in the pathophysiology of schizophrenia. In our study …
and microglia, a major source of ROS, in the pathophysiology of schizophrenia. In our study …
[HTML][HTML] Bridging cholinergic signalling and inflammation in schizophrenia
CN Metz, M Brines, VA Pavlov - Schizophrenia, 2024 - nature.com
Schizophrenia is a severe multifactorial mental illness and a leading cause of global
disability 1, 2. Current options for pharmacological treatment of schizophrenia are almost …
disability 1, 2. Current options for pharmacological treatment of schizophrenia are almost …
Functional Connectivity-Based Searchlight Multivariate Pattern Analysis for Discriminating Schizophrenia Patients and Predicting Clinical Variables
Y Chen, S Wang, X Zhang, Q Yang, M Hua… - Schizophrenia …, 2024 - academic.oup.com
Background Schizophrenia, a multifaceted psychiatric disorder characterized by functional
dysconnectivity, poses significant challenges in clinical practice. This study explores the …
dysconnectivity, poses significant challenges in clinical practice. This study explores the …
Longitudinal course of inflammatory-cognitive subgroups across first treatment severe mental illness and healthy controls
LS Saether, T Ueland, B Haatveit, A Vaskinn… - medRxiv, 2024 - medrxiv.org
Background While inflammation is associated with cognitive impairment in severe mental
illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic …
illnesses (SMI), there is substantial heterogeneity and evidence of transdiagnostic …
Brain heterogeneity in 1,792 individuals with schizophrenia: effects of illness stage, sites of origin and pathophysiology
Importance: Schizophrenia is characterized with greater variability beyond the mean
differences in brain structures. This variability is often assumed to be static, reflecting the …
differences in brain structures. This variability is often assumed to be static, reflecting the …
Macro-and Micro-Structural Alterations in the Midbrain in Early Psychosis
Z Zhou, K Jones, EI Ivleva, L Colon-Perez - bioRxiv, 2024 - biorxiv.org
Introduction. Early psychosis (EP) is a critical period in the course of psychotic disorders
during which the brain is thought to undergo rapid and significant functional and structural …
during which the brain is thought to undergo rapid and significant functional and structural …
[PDF][PDF] INDIVIDUAZIONE E TRAIETTORIE DEI SINTOMI PREPSICOTICI: VULNERABILITÀ COGNITIVA NEI DISTURBI DELL'UMORE
F Franza - researchgate.net
La riserva cognitiva è un fattore importante nel ridurre il naturale decadimento cognitivo.
Individuata nelle patologie neurodegenerative assume sempre di più un ruolo anche …
Individuata nelle patologie neurodegenerative assume sempre di più un ruolo anche …