[HTML][HTML] Hypoxic microenvironment in cancer: molecular mechanisms and therapeutic interventions

Z Chen, F Han, Y Du, H Shi, W Zhou - Signal transduction and targeted …, 2023 - nature.com
Having a hypoxic microenvironment is a common and salient feature of most solid tumors.
Hypoxia has a profound effect on the biological behavior and malignant phenotype of …

Tumor abnormality-oriented nanomedicine design

Q Zhou, J Xiang, N Qiu, Y Wang, Y Piao, S Shao… - Chemical …, 2023 - ACS Publications
Anticancer nanomedicines have been proven effective in mitigating the side effects of
chemotherapeutic drugs. However, challenges remain in augmenting their therapeutic …

[HTML][HTML] Thrombin induces ACSL4-dependent ferroptosis during cerebral ischemia/reperfusion

Q Tuo, Y Liu, Z Xiang, HF Yan, T Zou, Y Shu… - Signal transduction and …, 2022 - nature.com
Ischemic stroke represents a significant danger to human beings, especially the elderly.
Interventions are only available to remove the clot, and the mechanism of neuronal death …

The nucleus measures shape changes for cellular proprioception to control dynamic cell behavior

V Venturini, F Pezzano, F Catala Castro, HM Häkkinen… - Science, 2020 - science.org
INTRODUCTION Human beings are equipped with multiple senses (sight, hearing, smell,
taste, touch, and proprioception) to help them to react properly to their environment. The …

[HTML][HTML] The chemistry of snake venom and its medicinal potential

AL Oliveira, MF Viegas, SL da Silva… - Nature Reviews …, 2022 - nature.com
The fascination and fear of snakes dates back to time immemorial, with the first scientific
treatise on snakebite envenoming, the Brooklyn Medical Papyrus, dating from ancient Egypt …

[HTML][HTML] Functionalized liposomes for targeted breast cancer drug delivery

J Nel, K Elkhoury, É Velot, A Bianchi, S Acherar… - Bioactive materials, 2023 - Elsevier
Despite the exceptional progress in breast cancer pathogenesis, prognosis, diagnosis, and
treatment strategies, it remains a prominent cause of female mortality worldwide …

[HTML][HTML] The main bioactive compounds of Scutellaria baicalensis Georgi. for alleviation of inflammatory cytokines: A comprehensive review

H Liao, J Ye, L Gao, Y Liu - Biomedicine & Pharmacotherapy, 2021 - Elsevier
Scutellaria baicalensis Georgi., a plant used in traditional Chinese medicine, has multiple
biological activities, including anti-inflammatory, antiviral, antitumor, antioxidant, and …

Eicosanoids

PC Calder - Essays in Biochemistry, 2020 - portlandpress.com
This article describes the pathways of eicosanoid synthesis, eicosanoid receptors, the action
of eicosanoids in different physiological systems, the roles of eicosanoids in selected …

[HTML][HTML] Melatonin and phytomelatonin: Chemistry, biosynthesis, metabolism, distribution and bioactivity in plants and animals—An overview

G Mannino, C Pernici, G Serio, C Gentile… - International Journal of …, 2021 - mdpi.com
Melatonin is a ubiquitous indolamine, largely investigated for its key role in the regulation of
several physiological processes in both animals and plants. In the last century, it was …

[HTML][HTML] Synopsis of arachidonic acid metabolism: A review

VS Hanna, EAA Hafez - Journal of advanced research, 2018 - Elsevier
Abstract Arachidonic acid (AA), a 20 carbon chain polyunsaturated fatty acid with 4 double
bonds, is an integral constituent of biological cell membrane, conferring it with fluidity and …