Versatile and multivalent nanobodies efficiently neutralize SARS-CoV-2
Cost-effective, efficacious therapeutics are urgently needed to combat the COVID-19
pandemic. In this study, we used camelid immunization and proteomics to identify a large …
pandemic. In this study, we used camelid immunization and proteomics to identify a large …
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2
TF Custódio, H Das, DJ Sheward, L Hanke… - Nature …, 2020 - nature.com
The coronavirus SARS-CoV-2 is the cause of the ongoing COVID-19 pandemic. Therapeutic
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19 …
neutralizing antibodies constitute a key short-to-medium term approach to tackle COVID-19 …
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme
There are currently few approved effective treatments for SARS-CoV-2, the virus responsible
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
for the COVID-19 pandemic. Nanobodies are 12–15 kDa single-domain antibody fragments …
Perspective on therapeutic and diagnostic potential of camel nanobodies for coronavirus disease-19 (COVID-19)
S Bessalah, S Jebahi, N Mejri, I Salhi, T Khorchani… - 3 Biotech, 2021 - Springer
In this paper, we focus on the camelid nanobodies as a revolutionary therapy that can guide
efforts to discover new drugs for Coronavirus disease (COVID-19). The small size property …
efforts to discover new drugs for Coronavirus disease (COVID-19). The small size property …
Prediction and mitigation of mutation threats to COVID-19 vaccines and antibody therapies
Antibody therapeutics and vaccines are among our last resort to end the raging COVID-19
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
pandemic. They, however, are prone to over 5000 mutations on the spike (S) protein …
E484K mutation in SARS-CoV-2 RBD enhances binding affinity with hACE2 but reduces interactions with neutralizing antibodies and nanobodies: Binding free energy …
WB Wang, Y Liang, YQ Jin, J Zhang, JG Su… - Journal of Molecular …, 2021 - Elsevier
The pandemic of the COVID-19 disease caused by SARS-CoV-2 has led to more than 200
million infections and over 4 million deaths worldwide. The progress in the developments of …
million infections and over 4 million deaths worldwide. The progress in the developments of …
The role of single-domain antibodies (or nanobodies) in SARS-CoV-2 neutralization
The severe acute respiratory syndrome (SARS-CoV-2), a newly emerging of coronavirus,
continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that …
continues to infect humans in the absence of a viable treatment. Neutralizing antibodies that …
A potent neutralizing nanobody against SARS‐CoV‐2 with inhaled delivery potential
J Gai, L Ma, G Li, M Zhu, P Qiao, X Li, H Zhang… - MedComm, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has become a serious
burden on global public health. Although therapeutic drugs against COVID‐19 have been …
burden on global public health. Although therapeutic drugs against COVID‐19 have been …
[HTML][HTML] An ultra-potent synthetic nanobody neutralizes SARS-CoV-2 by locking Spike into an inactive conformation
Without an effective prophylactic solution, infections from SARS-CoV-2 continue to rise
worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host …
worldwide with devastating health and economic costs. SARS-CoV-2 gains entry into host …
A high-affinity RBD-targeting nanobody improves fusion partner's potency against SARS-CoV-2
H Yao, H Cai, T Li, B Zhou, W Qin, D Lavillette… - PLoS …, 2021 - journals.plos.org
A key step to the SARS-CoV-2 infection is the attachment of its Spike receptor-binding
domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the …
domain (S RBD) to the host receptor ACE2. Considerable research has been devoted to the …