mEthAE: an Explainable AutoEncoder for methylation data

S Katz, VAP Martins dos Santos, E Saccenti… - bioRxiv, 2023 - biorxiv.org
Despite the wealth of knowledge generated through epigenome-wide association studies
our understanding of the relationships of CpG sites is still limited, as analysis of DNA …

DNA Methylation Changes in Blood Cells of Fibromyalgia and Chronic Fatigue Syndrome Patients

PK Przybylowicz, KE Sokolowska, H Rola… - Journal of Pain …, 2023 - Taylor & Francis
Purpose Fibromyalgia (FM) and Chronic Fatigue Syndrome (CFS) affect 0.4% and 1% of
society, respectively, and the prevalence of these pain syndromes is increasing. To date, no …

Genome-wide Methylation Dynamics and Context-dependent Gene Expression Variability in Differentiating Preadipocytes

B Yadav, D Singh, S Mantri… - Journal of the Endocrine …, 2024 - academic.oup.com
Obesity, characterised by the accumulation of excess fat, is a complex condition resulting
from the combination of genetic and epigenetic factors. Recent studies have found …

A mixture of endocrine disrupting chemicals associated with lower birth weight in children induces Adipogenesis and DNA methylation changes in human …

P Lizunkova, E Engdahl, G Borbély… - International journal of …, 2022 - mdpi.com
Endocrine Disrupting Chemicals (EDCs) are man-made compounds that alter functions of
the endocrine system. Environmental mixtures of EDCs might have adverse effects on …

Exploring the epigenome to identify biological links between the urban environment and neurodegenerative disease: an evidence review

S Glover, C Hill, B McGuinness, AJ McKnight… - Cities & …, 2024 - Taylor & Francis
Global urbanisation has occurred in tandem with population ageing, having implications on
human cognitive health. Urban environmental factors such as air pollution are known risk …

Genetic Biomarkers of Psychiatric Disorders

M Farhan, E Soyebo, C Busby, GR Fries - Biomarkers in Neuropsychiatry …, 2023 - Springer
Psychiatric disorders are multifactorial conditions known to have a significant genetic
component, as seen in family, twin, and adoption studies. After decades of linkage and …

Antidepressant Exposure and DNA Methylation: Insights from a Methylome-Wide Association Study

E Davyson, X Shen, F Huider, M Adams, K Borges… - medRxiv, 2024 - medrxiv.org
Importance Understanding antidepressant mechanisms could help design more effective
and tolerated treatments. Objective Identify DNA methylation (DNAm) changes associated …

Post Stroke Motor Recovery Genome Wide Association Study: A Domain-Specific Approach

CM Aldridge, B Robynne, KL Keene, FC Hsu, MM Sale… - medRxiv, 2023 - medrxiv.org
Background In this genome wide association study (GWAS) we aimed to discover single
nucleotide polymorphisms (SNPs) associated with motor recovery post-stroke. Methods We …

Characterization of baseline and longitudinal DNA Methylation in patients with sporadic Parkinson's disease

P Gonzalez-Latapi, B Bustos, S Dong, S Lubbe… - medRxiv, 2023 - medrxiv.org
Objective To characterize DNA methylation differences between sporadic Parkinson's
Disease and healthy control individuals enrolled in the Parkinson's Progression Markers …

Birth history is associated with whole-blood and T-cell methylation patterns in relapse onset multiple sclerosis

MP Campagna, A Xavier, J Stankovich, V Maltby… - medRxiv, 2022 - medrxiv.org
Background Pregnancy in women with multiple sclerosis (MS) is associated with a reduction
of long-term disability progression. The mechanism that drives this effect is unknown, but …