Background Third-generation nanopore sequencers offer selective sequencing or “Read
Until” that allows genomic reads to be analyzed in real time and abandoned halfway if not …

We propose a novel dynamic storage-based approximate search content addressable
memory (DASH-CAM) for computational genomics applications, particularly for identification …

High-throughput sequencing (HTS) technologies have revolutionized the field of genomics,
enabling rapid and cost-effective genome analysis for various applications. However, the …

Improvements in nanopore sequencing necessitate efficient classification methods,
including pre-filtering and adaptive sampling algorithms that enrich for reads of interest …

Nanopore signal analysis enables detection of nucleotide modifications from native DNA
and RNA sequencing, providing both accurate genetic/transcriptomic and epigenetic …

Nanopore sequencers can enrich or deplete the targeted DNA molecules in a library by
reversing the voltage across individual nanopores. However, it requires substantial …

Profile hidden Markov models (pHMMs) are widely employed in various bioinformatics
applications to identify similarities between biological sequences, such as DNA or protein …

Nanopore-based sequencers generate a series of raw electrical signal measurements that
represent the contents of a biological sequence molecule passing through the sequencer's …

Raw nanopore signals can be analyzed while they are being generated, a process known
as real-time analysis. Real-time analysis of raw signals is essential to utilize the unique …

Abstract Motivation The Oxford Nanopore Technologies (ONT) ReadUntil API enables
selective sequencing, which aims to selectively favor interesting over uninteresting reads …