Platelets in healthy and disease states: from biomarkers discovery to drug targets identification by proteomics

E Gianazza, M Brioschi, R Baetta, A Mallia… - International journal of …, 2020 - mdpi.com
Platelets are a heterogeneous small anucleate blood cell population with a central role both
in physiological haemostasis and in pathological states, spanning from thrombosis to …

Flavonoids as potential anti-platelet aggregation agents: from biochemistry to health promoting abilities

J Sharifi-Rad, C Quispe, S Shaheen… - Critical Reviews in …, 2022 - Taylor & Francis
Cardiovascular ailments are the number one cause of mortalities throughout the globe with
17.9 million deaths per year. Platelet activation and aggregation play a crucial role in the …

Interventions supporting long term adherence and decreasing cardiovascular events after myocardial infarction (ISLAND): pragmatic randomised controlled trial

NM Ivers, JD Schwalm, Z Bouck, T McCready… - bmj, 2020 - bmj.com
Objective To test a scalable health system intervention to improve long term adherence to
secondary prevention treatments among patients who have had a recent myocardial …

Dual antiplatelet therapy in coronary artery disease

R Sharma, P Kumar, SP Prashanth, Y Belagali - Cardiology and therapy, 2020 - Springer
Acute coronary syndrome (ACS) is principally driven by platelet aggregation. Dual
antiplatelet therapy (DAPT) has demonstrated a reduction in recurrent ischemic events. The …

Study of the structure of hyperbranched polyglycerol coatings and their antibiofouling and antithrombotic applications

E Moore, AJ Robson, AR Crisp… - Advanced …, 2024 - Wiley Online Library
While blood‐contacting materials are widely deployed in medicine in vascular stents,
catheters, and cannulas, devices fail in situ because of thrombosis and restenosis …

Antiplatelet agents affecting GPCR signaling implicated in tumor metastasis

G Rovati, A Contursi, A Bruno, S Tacconelli, P Ballerini… - Cells, 2022 - mdpi.com
Metastasis requires that cancer cells survive in the circulation, colonize distant organs, and
grow. Despite platelets being central contributors to hemostasis, leukocyte trafficking during …

Diabetes mellitus y riesgo cardiovascular: actualización de las recomendaciones del Grupo de Trabajo de Diabetes y Enfermedad Cardiovascular de la Sociedad …

F Arrieta, J Pedro-Botet, P Iglesias, JC Obaya… - Clínica e investigación …, 2022 - Elsevier
El presente documento es una actualización de las recomendaciones de práctica clínica
para el manejo de los factores de riesgo cardiovascular (FRCV) en la diabetes mellitus. Este …

Impact of the Chinese herbal medicines on dual antiplatelet therapy with clopidogrel and aspirin: pharmacokinetics and pharmacodynamics outcomes and related …

M Xiao, C Qian, X Luo, M Yang, Y Zhang, C Wu… - Journal of …, 2019 - Elsevier
Ethnopharmacological relevance Dual antiplatelet therapy (DAPT) with aspirin (ASA) and
clopidogrel (CLP) has been consistently shown clinical effectiveness in patients with …

Thrombin generation as a method to identify the risk of bleeding in high clinical-risk patients using dual antiplatelet therapy

CPDM de Breet, S Zwaveling, MJA Vries… - Frontiers in …, 2021 - frontiersin.org
Background: Patients using dual antiplatelet therapy after percutaneous coronary
intervention are at risk for bleeding. It is currently unknown whether thrombin generation can …

Phosphoinositide 3-kinases as potential targets for thrombosis prevention

NM Setiabakti, P Larsson, JR Hamilton - International Journal of …, 2022 - mdpi.com
As integral parts of pathological arterial thrombi, platelets are the targets of pharmacological
regimens designed to treat and prevent thrombosis. A detailed understanding of platelet …