Systemic sclerosis (SSc) is a complex disease characterized by early microvascular
abnormalities, immune dysregulation and chronic inflammation, and subsequent fibrosis of …

Systemic sclerosis (SSc) is an idiopathic systemic autoimmune disease. It is characterized
by a triad of hallmarks: immune dysfunction, fibrosis and vasculopathy. Immune dysfunction …

Background Pro-inflammatory fibroblasts are critical for pathogenesis in rheumatoid arthritis,
inflammatory bowel disease, interstitial lung disease, and Sjögren's syndrome and represent …

Systemic sclerosis (SSc) is an autoimmune fibrotic disease whose pathogenesis is poorly
understood and lacks effective therapies. We undertook quantitative analyses of T cell …

Objective To determine mortality and causes of death in a multinational inception cohort of
subjects with systemic sclerosis (SSc). Methods We quantified mortality as standardized …

Systemic sclerosis (SSc) is a devastating autoimmune disease characterized by excessive
production and accumulation of extracellular matrix, leading to fibrosis of skin and other …

Systemic sclerosis (SS c) is a multisystem autoimmune disease characterized by
vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic …

Systemic Sclerosis (SSc) is an autoimmune disease marked by dysregulation of the immune
system, tissue fibrosis and dysfunction of the vasculature. Vascular damage, remodeling and …

In early systemic sclerosis (Scleroderma, SSc), the vasculature is impaired. Although the
exact etiology of endothelial cell damage in SSc remains unclear, it is hypothesized that …

Background Cardiovascular involvement in systemic sclerosis (SS c) comprises a wide
range of manifestations with prevalence and incidence that remain uncertain. Methods and …