Advancement in solubilization approaches: a step towards bioavailability enhancement of poorly soluble drugs

L Kumari, Y Choudhari, P Patel, GD Gupta, D Singh… - Life, 2023 - mdpi.com
A drug's aqueous solubility is defined as the ability to dissolve in a particular solvent, and it
is currently a major hurdle in bringing new drug molecules to the market. According to some …

Delivering on the promise of protein degraders

MN O'Brien Laramy, S Luthra, MF Brown… - Nature Reviews Drug …, 2023 - nature.com
Over the past 3 years, the first bivalent protein degraders intentionally designed for targeted
protein degradation (TPD) have advanced to clinical trials, with an initial focus on …

[HTML][HTML] Oral drug delivery strategies for development of poorly water soluble drugs in paediatric patient population

S Salunke, F O'Brien, DCT Tan, D Harris… - Advanced Drug Delivery …, 2022 - Elsevier
Selecting the appropriate formulation and solubility-enabling technology for poorly water
soluble drugs is an essential element in the development of formulations for paediatric …

[HTML][HTML] Hydrogel-forming microarray patches with solid dispersion reservoirs for transdermal long-acting microdepot delivery of a hydrophobic drug

YA Naser, IA Tekko, LK Vora, K Peng, QK Anjani… - Journal of Controlled …, 2023 - Elsevier
Hydrogel-forming microarray patches (HF-MAPs) are used to circumvent the skin barrier and
facilitate the noninvasive transdermal delivery of many hydrophilic substances. However …

Advances in lipid-based carriers for cancer therapeutics: Liposomes, exosomes and hybrid exosomes

DN Moholkar, R Kandimalla, RC Gupta, F Aqil - Cancer Letters, 2023 - Elsevier
Cancer has recently surpassed heart disease as the leading cause of deaths worldwide for
the age group 45–65 and has been the primary focus for biomedical researchers. Presently …

Strategies for oral delivery of bioactive peptides with focus on debittering and masking

A Mirzapour-Kouhdasht, DJ McClements… - npj Science of …, 2023 - nature.com
Protein hydrolysis is a process used in the food industry to generate bioactive peptides of
low molecular weight and with additional health benefits, such as antihypertensive …

Current trends on solid dispersions: past, present, and future

R Malkawi, WI Malkawi, Y Al-Mahmoud… - Advances in …, 2022 - Wiley Online Library
Solid dispersions have achieved significant interest as an effective means of enhancing the
dissolution rate and thus the bioavailability of a range of weakly water‐soluble drugs. Solid …

Amorphous solid dispersions (asds): The influence of material properties, manufacturing processes and analytical technologies in drug product development

R Iyer, V Petrovska Jovanovska, K Berginc, M Jaklič… - Pharmaceutics, 2021 - mdpi.com
Poorly water-soluble drugs pose a significant challenge to developability due to poor oral
absorption leading to poor bioavailability. Several approaches exist that improve the oral …

[PDF][PDF] RETRACTED ARTICLE: Potential of solid dispersions to enhance solubility, bioavailability, and therapeutic efficacy of poorly water-soluble drugs: newer …

S Alshehri, SS Imam, A Hussain, MA Altamimi… - Drug …, 2020 - Taylor & Francis
Abstract We, the Editors and Publisher of Drug Delivery have retracted the following article:
Sultan Alshehri, Syed Sarim Imam, Afzal Hussain, Mohammad A. Altamimi, Nabil K …

Microarray patches: poking a hole in the challenges faced when delivering poorly soluble drugs

AJ Paredes, PE McKenna, IK Ramöller… - Advanced Functional …, 2021 - Wiley Online Library
Poorly soluble drugs constitute more than 60% of currently marketed pharmaceuticals with
over two‐thirds of promising new chemical entities failing to enter a clinical setting due to …