This paper is the thirty-ninth consecutive installment of the annual review of research
concerning the endogenous opioid system. It summarizes papers published during 2016 …

Quite intuitive is the notion that memory formation and consolidation is orchestrated by
protein synthesis because of the synaptic plasticity necessary for those processes …

Background Opioids are widely used in clinical practice. However, their long-term
administration causes respiratory depression, addiction, tolerance, and severe …

Undoubtedly, opioid drugs have been the most popular treatment for refractory pain since
found, such as morphine. However, tolerance to the analgesic effects caused by repeated …

DNA cytosine methylation has been documented as a potential epigenetic mechanism of
transcriptional regulation underlying opioid use disorder. However, methylation of RNA …

As a significant public health issue, chronic pain, mainly neuropathic pain (NP) and
inflammatory pain, has a severe impact. The underlying mechanisms of chronic pain are …

It is well accepted that treatment of chronic pain with morphine leads to μ opioid receptor
(MOR) desensitization and the development of morphine tolerance. MOR activation by the …

Signaling by classic analgesics, such as morphine, is governed primarily by the relative
abundance of opioid receptors at the cell surface, and this is regulated by receptor delivery …

This work aimed to test the effect of 7-day exposure of rats to multifunctional enkephalin
analogs LYS739 and LYS744 at doses of 3 mg/kg and 10 mg/kg on the protein composition …

We deployed an online pain sensitivity questionnaire (PSQ) and an at-home version of the
cold pressor test (CPT) in a large genotyped cohort. We performed genome-wide …