An automated feeding system for the African killifish reveals the impact of diet on lifespan and allows scalable assessment of associative learning

A McKay, EK Costa, J Chen, CK Hu, X Chen… - Elife, 2022 - elifesciences.org
The African turquoise killifish is an exciting new vertebrate model for aging studies. A
significant challenge for any model organism is the control over its diet in space and time. To …

Regulation of feeding and energy homeostasis by clock-mediated Gart in Drosophila

L He, B Wu, J Shi, J Du, Z Zhao - Cell Reports, 2023 - cell.com
Feeding behavior is essential for growth and survival of animals; however, relatively little is
known about its intrinsic mechanisms. Here, we demonstrate that Gart is expressed in the …

The role of intermittent fasting and dieting on cognition in adult population: a systematic review of the randomized controlled trials

H Senderovich, O Farahneh, S Waicus - Medical Principles and …, 2023 - karger.com
Objective: A healthy diet is a modifiable risk factor that may impact cognition. A unique type
of diet may include intermittent fasting (IF), an eating pattern in which individuals go …

Abalone peptide increases stress resilience and cost‐free longevity via SKN‐1‐governed transcriptional metabolic reprogramming in C. elegans

Q Wang, L Wang, Z Huang, Y Xiao, M Liu, H Liu… - Aging …, 2024 - Wiley Online Library
A major goal of healthy aging is to prevent declining resilience and increasing frailty, which
are associated with many chronic diseases and deterioration of stress response. Here, we …

Late-life shift in caloric intake affects fly metabolism and longevity

M Li, J Macro, K Meadows, D Mishra… - Proceedings of the …, 2023 - National Acad Sciences
The prevalence of obesity is increasing in older adults and contributes to age-related
decline. Caloric restriction (CR) alleviates obesity phenotypes and delays the onset of age …

Icariin Improves Stress Resistance and Extends Lifespan in Caenorhabditis elegans through hsf-1 and daf-2-Driven Hormesis

MN Todorova, MS Savova, LV Mihaylova… - International Journal of …, 2023 - mdpi.com
Aging presents an increasingly significant challenge globally, driven by the growing
proportion of individuals aged 60 and older. Currently, there is substantial research interest …

The role of DNA damage in neural stem cells ageing

Y Zhong, G Wang, S Yang, Y Zhang… - Journal of Cellular …, 2024 - Wiley Online Library
Neural stem cells (NSCs) are pluripotent stem cells with the potential to differentiate into a
variety of nerve cells. NSCs are susceptible to both intracellular and extracellular insults …

The ABC-associated immunosenescence and lifestyle interventions in autoimmune disease

P Ruan, S Wang, M Yang, H Wu - Rheumatology and Immunology …, 2022 - degruyter.com
Aging-associated immune changes, termed immunosenescence, occur with impaired robust
immune responses. This immune response is closely related to a greater risk of …

Glycative stress as a cause of macular degeneration

E Bejarano, A Domenech-Bendaña… - Progress in Retinal and …, 2024 - Elsevier
People are living longer and rates of age-related diseases such as age-related macular
degeneration (AMD) are accelerating, placing enormous burdens on patients and health …

Night eating in timing, frequency, and food quality and risks of all-cause, cancer, and diabetes mortality: findings from national health and nutrition examination survey

P Wang, Q Tan, Y Zhao, J Zhao, Y Zhang, D Shi - Nutrition & Diabetes, 2024 - nature.com
Objective To investigate the association of timing, frequency, and food quality of night eating
with all-cause, cancer, and diabetes mortality. Methods This study included 41,744 …