Microbiome-based therapeutics

MT Sorbara, EG Pamer - Nature Reviews Microbiology, 2022 - nature.com
Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

The intestinal microbiota: antibiotics, colonization resistance, and enteric pathogens

S Kim, A Covington, EG Pamer - Immunological reviews, 2017 - Wiley Online Library
The human gastrointestinal tract hosts a diverse network of microorganisms, collectively
known as the microbiota that plays an important role in health and disease. For instance, the …

Mucosal immunity–mediated modulation of the gut microbiome by oral delivery of probiotics into Peyer's patches

S Lin, S Mukherjee, J Li, W Hou, C Pan, J Liu - Science advances, 2021 - science.org
Methods capable of maintaining gut microbiota homeostasis to prevent bacterial
translocation and infection under external threats are critical for multiple facets of human …

Functional and genomic variation between human-derived isolates of Lachnospiraceae reveals inter-and intra-species diversity

MT Sorbara, ER Littmann, E Fontana, TU Moody… - Cell host & …, 2020 - cell.com
Bacteria belonging to the Lachnospiraceae family are abundant, obligate anaerobic
members of the microbiota in healthy humans. Lachnospiraceae impact their hosts by …

[HTML][HTML] Relationship between intestinal microbiota and ulcerative colitis: Mechanisms and clinical application of probiotics and fecal microbiota transplantation

ZH Shen, CX Zhu, YS Quan, ZY Yang… - World journal of …, 2018 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is an inflammatory disease that mainly affects the colon and rectum. It
is believed that genetic factors, host immune system disorders, intestinal microbiota …

Bifidobacteria and butyrate-producing colon bacteria: importance and strategies for their stimulation in the human gut

A Rivière, M Selak, D Lantin, F Leroy… - Frontiers in …, 2016 - frontiersin.org
With the increasing amount of evidence linking certain disorders of the human body to a
disturbed gut microbiota, there is a growing interest for compounds that positively influence …

Antibiotic-induced collateral damage to the microbiota and associated infections

L de Nies, CM Kobras, M Stracy - Nature Reviews Microbiology, 2023 - nature.com
Antibiotics have transformed medicine, saving millions of lives since they were first used to
treat a bacterial infection. However, antibiotics administered to target a specific pathogen …

A cross-talk between microbiota-derived short-chain fatty acids and the host mucosal immune system regulates intestinal homeostasis and inflammatory bowel …

P Gonçalves, JR Araújo… - Inflammatory bowel …, 2018 - academic.oup.com
Gut microbiota has a fundamental role in the energy homeostasis of the host and is essential
for proper “education” of the immune system. Intestinal microbial communities are able to …

[HTML][HTML] Microorganisms with claimed probiotic properties: an overview of recent literature

S Fijan - International journal of environmental research and …, 2014 - mdpi.com
Probiotics are defined as live microorganisms, which when administered in adequate
amounts, confer a health benefit on the host. Health benefits have mainly been …

Defining dysbiosis and its influence on host immunity and disease

C Petersen, JL Round - Cellular microbiology, 2014 - Wiley Online Library
Mammalian immune system development depends on instruction from resident commensal
microorganisms. Diseases associated with abnormal immune responses towards …