Extracellular histones activate endothelial NLRP3 inflammasome and are associated with a severe sepsis phenotype
J Beltrán-García, R Osca-Verdegal… - Journal of …, 2022 - Taylor & Francis
Introduction Circulating extracellular histones acquire relevance as cytotoxic mediators in
sepsis. Extracellular histones act as damage-associated molecular patterns (DAMPs), which …
sepsis. Extracellular histones act as damage-associated molecular patterns (DAMPs), which …
Heparin-functionalized adsorbents eliminate central effectors of immunothrombosis, including platelet factor 4, high-mobility group box 1 protein and histones
M Ebeyer-Masotta, T Eichhorn, R Weiss… - International Journal of …, 2022 - mdpi.com
Inflammation and thrombosis are closely intertwined in numerous disorders, including
ischemic events and sepsis, as well as coronavirus disease 2019 (COVID-19). Thrombotic …
ischemic events and sepsis, as well as coronavirus disease 2019 (COVID-19). Thrombotic …
Noninvasive nasopharyngeal proteomics of COVID-19 patient identify abnormalities related to complement and coagulation cascade and mucosal immune system
MA Ayass, W Cao, J Zhang, J Dai, K Zhu, T Tripathi… - Plos one, 2022 - journals.plos.org
Serum or plasma have been the primary focus of proteomics studies for COVID-19 to identity
biomarkers and potential drug targets. The nasal mucosal environment which consists of …
biomarkers and potential drug targets. The nasal mucosal environment which consists of …
Self-DNA driven inflammation in COVID-19 and after mRNA-based vaccination: lessons for non-COVID-19 pathologies
M Heil - Frontiers in Immunology, 2024 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic triggered an unprecedented
concentration of economic and research efforts to generate knowledge at unequalled speed …
concentration of economic and research efforts to generate knowledge at unequalled speed …
Serum level of total histone 3, H3K4me3, and H3K27ac after non-emergent cardiac surgery suggests the persistence of smoldering inflammation at 3 months in an …
K Laudanski, D Liu, J Hajj, D Ghani, WY Szeto - Clinical Epigenetics, 2022 - Springer
Background Despite clinical relevance of immunological activation due to histone leakage
into the serum following cardiac surgery, long-term data describing their longitudinal …
into the serum following cardiac surgery, long-term data describing their longitudinal …
Therapeutic Approaches for Intravascular Microthrombi-induced Acute Respiratory Distress Syndrome (ARDS) in COVID-19 Infection
KM Gopika, S Sivajith, A Sugunan… - Current …, 2023 - ingentaconnect.com
The COVID-19 pandemic has overwhelmed our health care capacity in an unprecedented
way due to the sheer number of critically infected patients admitted to hospitals during the …
way due to the sheer number of critically infected patients admitted to hospitals during the …