Histone proteins and the nucleosomes they form with DNA are the fundamental building
blocks of eukaryotic chromatin. A diverse array of post-translational modifications that often …

Roger D. Kornberg* and Yahli Lorch Department of Structural Biology Stanford University
School of Medicine Stanford, California 94305 model building and other predictive structural …

The transcription factors HNF3 (FoxA) and GATA-4 are the earliest known to bind the
albumin gene enhancer in liver precursor cells in embryos. To understand how they access …

Impaired wound healing is a major secondary complication of type 2 diabetes that often
results in limb loss and disability. Normal tissue repair progresses through discrete phases …

▪ Abstract The past decade has seen an explosive increase in information about regulation
of eukaryotic gene transcription, especially for protein-coding genes. The most striking …

The nucleosome, which is the primary building block of chromatin, is not a static structure: It
can adopt alternative conformations. Changes in solution conditions or changes in histone …

CNRS–INSERM–ULP, BP 163 other studies, the C-terminal histone-fold domains of core
histones have similar conformations that are critical 67404 Illkirch, Strasbourg France for the …

▪ Abstract Thyroid hormone is essential for normal development, differentiation, and
metabolic balance. Thyroid hormone action is mediated by multiple thyroid hormone …

Reversible acetylation of core histone tails plays an important role in the regulation of
eukaryotic transcription, in the formation of repressive chromatin complexes, and in the …

The importance of histones and chromatin structure in the regulation of eukaryotic gene
transcription has become much more widely accepted over the past few years. It has been …