Bone defects repair and regeneration by various causes such as tumor resection, trauma,
degeneration, etc. have always been a key issue in the clinics. As one of the few organs that …

Osteoporosis is a progressive skeletal disease characterized by decreased bone mass and
degraded bone microstructure, which leads to increased bone fragility and risks of bone …

Mesenchymal stem cells (MSCs) are multipotent cells that represent a promising source for
regenerative medicine. MSCs are capable of osteogenic, chondrogenic, adipogenic and …

Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the
hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem …

Therapeutic approaches to metabolic syndrome (MetS) are numerous and may target
lipoproteins, blood pressure or anthropometric indices. Peroxisome proliferator-activated …

The multiple endocrine functions of bone other than those related to mineral metabolism,
such as regulation of insulin sensitivity, glucose homeostasis, and energy metabolism, have …

Musculoskeletal disorders (MSDs) are conditions that can affect muscles, bones, and joints.
These disorders are very painful and severely limit patients' mobility and are more common …

Long-chain polyunsaturated fatty acids (LCPUFAs) and their metabolites are considered
essential factors to support bone and joint health. The n-6 PUFAs suppress the osteoblasts …

Recent findings about cell fate change induced by physical stimuli have expedited the
discovery of underlying regulatory mechanisms that determine stem cell differentiation …

Presently, there is a high paucity of bone grafts in the United States and worldwide.
Regenerating bone is of prime concern due to the current demand of bone grafts and the …